Results 21 to 30 of about 1,905 (165)
Impaired antibody-mediated protection and defective IgA B cell memory in experimental infection of adults with respiratory syncytial virus [PDF]
, 2015 Rationale: Despite relative antigenic stability, respiratory syncytial virus (RSV) re-infects throughout life. After >40 years of research, no effective human vaccine exists and correlates of protection remain poorly defined.
Chiu, C +10 more
core +6 more sources
Pokeweed Antiviral Protein Accesses Ribosomes by Binding to L3 [PDF]
Journal of Biological Chemistry, 1999 Pokeweed antiviral protein (PAP), a 29-kDa ribosome-inactivating protein, catalytically removes an adenine residue from the conserved alpha-sarcin loop of the large rRNA, thereby preventing the binding of eEF-2.GTP complex during protein elongation. Because the alpha-sarcin loop has been placed near the peptidyltransferase center in Escherichia coli ...
K A, Hudak, J D, Dinman, N E, Tumer
openaire +2 more sources
BMC Biotechnology, 2018 Background Ricin A chain (RTA) and Pokeweed antiviral proteins (PAPs) are plant-derived N-glycosidase ribosomal-inactivating proteins (RIPs) isolated from Ricinus communis and Phytolacca Americana respectively. This study was to investigate the potential
Yasser Hassan, Sherry Ogg, Hui Ge
doaj +1 more source
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Phytohormones and emerging plant growth regulators in tailoring plant immunity against viral infections. [PDF]
Physiol PlantAbstract Viral infections are major contributors to crop yield loss and represent a significant threat to sustainable agriculture. Plants respond to virus attacks by activating sophisticated signalling cascades that initiate multiple defence mechanisms.
Shukla K +4 more
europepmc +2 more sources
The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]
, 1984 During the acute cytolytic T lymphocyte (CTL) response of mice to infection with the murine cytomegalovirus two independent populations of activated interleukin-receptive CTL precursors can be demonstrated.
Ada +25 more
core +1 more source
A double safety lock tumor-specific device for suicide gene therapy in breast cancer [PDF]
, 2020 Producción CientíficaThe complexity and continuous evolution of cancer make the design of novel strategies of treatment a constant challenge in biomedicine.
Arias Vallejo, Francisco Javier +5 more
core +2 more sources
Molecular Plant Pathology, Volume 21, Issue 9, Page 1212-1226, September 2020., 2020 Application or overexpression of α‐MMC in Nicotiana benthamiana increased resistance to TMV infection by means of modulating ROS homeostasis through controlling the expression of antioxidant enzyme‐encoding genes. Abstract Alpha‐momorcharin (α‐MMC), a member of the plant ribosomal inactivating proteins (RIPs) family, has been proven to exhibit ...
Feng Zhu +5 more
wiley +1 more source
The future of antiviral immunotoxins [PDF]
, 2016 There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments.
Høy Jakobsen, Mette +3 more
core +1 more source