Results 11 to 20 of about 3,449,279 (150)
Depurination of plant ribosomes by pokeweed antiviral protein [PDF]
FEBS Letters, 1990 Mammalian ribosomes have been shown to be enzymatically modified by ribosomal inactivating protein (RIPs) via specific depurination of rRNA. Here we report that ribosomes isolated from wheat germ contain intact and undepurinated rRNA and are depurinated by pokeweed antiviral protein (PAP).
J D Irvin
exaly +5 more sources
Poliovirus-mediated entry of pokeweed antiviral protein. [PDF]
Antimicrob Agents Chemother, 1990 Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. Cell permeabilization was dependent on the integrity of virus capsid proteins and directly proportional to the multiplicity of infection. This study demonstrates that virus adsorption is sufficient for the entry of pokeweed antiviral protein into ...
Lee T +4 more
europepmc +4 more sources
Effect of pokeweed antiviral protein (PAP) on the infection of plant viruses
Plant Pathology, 1991 At a concentration of 0.4 μg purified pokeweed antiviral protein (PAP)/ml, the formation of local lesions on tobacco leaves caused by tobacco mosaic virus infection was completely inhibited and at 25 ng PAP/ ml. 68% inhibition was still obtained. PAP protected plants from infection by viruses from seven virus groups‐five RNA viruses: tobacco mosaic ...
Chen, Z. C. +3 more
openaire +2 more sources
Inhibition of hepatitis B virus replication by pokeweed antiviral protein in vitro. [PDF]
World J Gastroenterol, 2008 To explore the inhibitory effects of pokeweed antiviral protein seed (PAP-S) and PAP encoded by a eukaryotic expression plasmid on hepatitis B virus (HBV) replication in vitro.HepG2 2.2.15 cells in cultured medium were treated with different concentrations of PAP-S.
He YW, Guo CX, Pan YF, Peng C, Weng ZH.
europepmc +3 more sources
Improved pokeweed genome assembly and early gene expression changes in response to jasmonic acid [PDF]
BMC Plant BiologyBackground Jasmonic acid (JA) is a phytohormone involved in regulating responses to biotic and abiotic stress. Although the JA pathway is well characterized in model plants such as Arabidopsis thaliana, less is known about many non-model plants ...
Kyra Dougherty +2 more
doaj +2 more sources
Extracellular localization of pokeweed antiviral protein. [PDF]
Proc Natl Acad Sci U S A, 1986 Pokeweed antiviral protein is an enzyme of Mr 29,000 known to inactivate a wide variety of eukaryotic ribosomes. We have used electron microscopy to show that the antibody specific for the protein is bound within the cell wall matrix of leaf mesophyll cells from Phytolacca americana. Any penetration or breakage of the cell wall and membrane could allow
Ready MP, Brown DT, Robertus JD.
europepmc +4 more sources
Identification of a biological inactive complex form of pokeweed antiviral protein [PDF]
FEBS Letters, 1997 Pokeweed antiviral protein (PAP) inactivates both eukaryotic and prokaryotic ribosomes via a specific depurination of rRNA. The sensitivity of pokeweed ribosomes to PAP implies the existence of a mechanism to protect the plant. Using monoclonal antibodies specific to PAP, a protein complex (PAPi) which contained PAP was identified in leaf extract.
Benedicte Desvoyes, Jean-Luc Poyet
exaly +3 more sources
FEBS Letters, 1982 Pokeweed antiviral protein (PAP) is a protein known to inactivate eukaryotic ribosomes by an unknown enzymatic action and inhibit the production of mammalian viruses in tissue culture. This protein was subjected to a variety of chemical modifications to determine their effects upon ribosomal inactivation, antiviral action, and cytotoxicity.
J D Irvin
exaly +3 more sources
Virus Research, 2013 Pokeweed antiviral protein (PAP) is a plant-derived N-glycosidase ribosomal-inactivating protein isolated from Phytolacca americana. The antiviral activity of PAP has been described in several viruses. This study was to investigate the antiviral activity of PAP against Japanese encephalitis virus (JEV) infection in vitro and in vivo. Antiviral activity
Chen Li, Hassan Z A Ishag
exaly +3 more sources
A novel case of autosomal recessive CARD11 loss-of-function underlying impaired antiviral immunity and a review of literature. [PDF]
Clin Transl ImmunologyWe report on a patient homozygous for a novel autosomal recessive loss‐of‐function CARD11 variant, with susceptibility to live attenuated virus (LAV) vaccines and impaired clearance of multiple naturally acquired respiratory viral infections. Inborn errors of immunity affecting the CARD11‐BCL10‐MALT1 (CBM) complex should be considered in individuals ...
Anderson H +12 more
europepmc +2 more sources