Inhibition of herpes simplex virus DNA synthesis by pokeweed antiviral protein [PDF]
Antimicrobial Agents and Chemotherapy, 1983 Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus yields than was the simultaneous ...
G J, Teltow, J D, Irvin, G M, Aron
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Pokeweed Antiviral Protein Inhibits Brome Mosaic Virus Replication in Plant Cells [PDF]
Journal of Biological Chemistry, 2005 Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein isolated from the pokeweed plant (Phytolacca americana) that inhibits the proliferation of several plant and animal viruses. We have shown previously that PAP and nontoxic mutants of PAP can directly depurinate brome mosaic virus (BMV) RNA in vitro, resulting in reduced viral protein ...
Daniel, Picard +2 more
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Dianthin and Its Potential in Targeted Tumor Therapies [PDF]
, 2019 Dianthin enzymes belong to ribosome-inactivating proteins (RIPs) of type 1, i.e., they only consist of a catalytic domain and do not have a cell binding moiety.
Fuchs, Hendrik
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Modeling and Alanine Scanning Mutagenesis Studies of Recombinant Pokeweed Antiviral Protein [PDF]
Journal of Biological Chemistry, 2000 The Phytolacca americana-derived naturally occurring ribosome inhibitory protein pokeweed antiviral protein (PAP) is an N-glycosidase that catalytically removes a specific adenine residue from the stem loop of ribosomal RNA. We have employed molecular modeling studies using a novel model of PAP-RNA complexes and site-directed mutagenesis combined with ...
F, Rajamohan +3 more
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Cytokine and immunoglobulin production by PWM-stimulated peripheral and tumor-infiltrating lymphocytes of undifferentiated nasopharyngeal carcinoma (NPC) patients [PDF]
, 2004 Background Undifferentiated Nasopharyngeal Carcinoma (NPC) patients show a characteristic pattern of antibody responses to the Epstein-Barr virus (EBV) which is regularly associated with this tumor.
Lilia Fliss-Jaber +41 more
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Identification of a biological inactive complex form of pokeweed antiviral protein [PDF]
FEBS Letters, 1997 Pokeweed antiviral protein (PAP) inactivates both eukaryotic and prokaryotic ribosomes via a specific depurination of rRNA. The sensitivity of pokeweed ribosomes to PAP implies the existence of a mechanism to protect the plant. Using monoclonal antibodies specific to PAP, a protein complex (PAPi) which contained PAP was identified in leaf extract.
Desvoyes, Bénédicte +5 more
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Inhibition of herpes simplex virus multiplication by the pokeweed antiviral protein [PDF]
Antimicrobial Agents and Chemotherapy, 1980 The pokeweed antiviral protein inhibited the multiplication of herpes simplex virus type 1 in cell culture. The extent of antiviral activity was proportional to the length of time that the antiviral protein was present postinfection. The results demonstrate that the continued presence of the pokeweed antiviral protein is necessary for the maximum ...
G M, Aron, J D, Irvin
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Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans [PDF]
, 2010 Background Astaxanthin modulates immune response, inhibits cancer cell growth, reduces bacterial load and gastric inflammation, and protects against UVA-induced oxidative stress in in vitro and rodent models.
Jean Park +4 more
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A double safety lock tumor-specific device for suicide gene therapy in breast cancer [PDF]
, 2020 Producción CientíficaThe complexity and continuous evolution of cancer make the design of novel strategies of treatment a constant challenge in biomedicine.
Arias Vallejo, Francisco Javier +5 more
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, 2008 We studied the in vitro and in planta antiviral activity of the PhRIP I, a type 1 Ribosome-Inactivating Protein originally purified from leaves of the Phytolacca heterotepala.
ANTIMO DI MARO +6 more
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