Results 31 to 40 of about 13,981 (252)

Late Pleistocene polar bear genomes reveal the timing of allele fixation in key genes associated with Arctic adaptation

BMC Genomics
The polar bear (Ursus maritimus) occupies a relatively narrow ecological niche, with many traits adapted for cold temperatures, movement across snow, ice and open water, and for consuming highly lipid-dense prey species.
Yulin Sun, Eline D. Lorenzen, Michael V. Westbury   +2 more
doaj   +1 more source

Polar Bears in a Warming Climate [PDF]

Integrative and Comparative Biology, 2004
Polar bears (Ursus maritimus) live throughout the ice-covered waters of the circumpolar Arctic, particularly in near shore annual ice over the continental shelf where biological productivity is highest. However, to a large degree under scenarios predicted by climate change models, these preferred sea ice habitats will be substantially altered.
Andrew E, Derocher, Nicholas J, Lunn, Ian, Stirling   +2 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

High winds and melting sea ice trigger landward movement in a polar bear population of concern

Ecosphere, 2023
Some animal species are responding to climate change by altering the timing of events like mating and migration. Such behavioral plasticity can be adaptive, but it is not always.
Annie Kellner, Todd C. Atwood, David C. Douglas, Stewart W. Breck, George Wittemyer   +4 more
doaj   +1 more source

Processing references in context: when the polar bear does not meet a polar bear

Cognitive Processing, 2023
AbstractDiscourse understanding is hampered when missing or conflicting context information is given. In four experiments, we investigated what happens (a) when the definite determiner “the,” which presupposes existence and uniqueness, does not find a unique referent in the context or (b) when the appropriate use of the indefinite determiner is ...
Bettina Rolke, Mareike Kirsten, Verena C. Seibold, Susanne Dietrich, Ingo Hertrich   +4 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of sea ice decline and summer land use on polar bear home range size in the Beaufort Sea

Ecosphere, 2021
Animals responding to habitat loss and fragmentation may increase their home ranges to offset declines in localized resources or they may decrease their home ranges and switch to alternative resources.
Anthony M. Pagano, George M. Durner, Todd C. Atwood, David C. Douglas   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Polar bear attacks on humans: Implications of a changing climate

Wildlife Society Bulletin, 2017
Understanding causes of polar bear (Ursus maritimus) attacks on humans is critical to ensuring both human safety and polar bear conservation. Although considerable attention has been focused on understanding black (U. americanus) and grizzly (U.
James M. Wilder, Dag Vongraven, Todd Atwood, Bob Hansen, Amalie Jessen, Anatoly Kochnev, Geoff York, Rachel Vallender, Daryll Hedman, Melissa Gibbons   +9 more
doaj   +1 more source