Results 41 to 50 of about 13,981 (252)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Efficacy of deterrents for mitigating human‐polar bear conflict in northern Alaska

Wildlife Society Bulletin
A warming climate is negatively affecting Arctic species that rely on sea ice to perform their life history activities. Changing sea ice dynamics have led polar bears in many subpopulations to spend more time on land, increasing the potential for human ...
Susanne Miller, Ryan R. Wilson, Lindsey S. Mangipane, Nathan Gordon II, Andrew L. Von Duyke, Carla Sims‐Kayotuk   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Building the foundation for polar bear science: fifty years of research on polar bears in Western Hudson Bay

Arctic Science
In 1966, Environment and Climate Change Canada (ECCC) (then Canadian Wildlife Service) initiated a research program on polar bears (Ursus maritimus, Phipps, 1774) belonging to the Western Hudson Bay subpopulation (WH).
B.A. Biddlecombe, A.E. Derocher, E. Krebs, N.J. Lunn, D. McGeachy, E.S. Richardson   +5 more
doaj   +1 more source

Climate change and the increasing impact of polar bears on bird populations

Frontiers in Ecology and Evolution, 2015
The Arctic is becoming warmer at a high rate, and contractions in the extent of sea ice are currently changing the habitats of marine top-predators dependent on ice. Polar bears (Ursus maritimus) depend on sea ice for hunting seals.
Jouke eProp, Jon eAars, Bård-Jørgen eBårdsen, Sveinn Are eHanssen, Claus eBech, Sophie eBourgeon, Jimmy ede Fouw, Geir Wing eGabrielsen, Johannes eLang, Johannes eLang, Elin eNoreen, Thomas eOudman, Benoit eSittler, Benoit eSittler, Lech eStempniewicz, Ingunn eTombre, Eva eWolters, Børge eMoe   +17 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Anthropogenic flank attack on polar bears: Interacting consequences of climate warming and pollutant exposure

Frontiers in Ecology and Evolution, 2015
Polar bears (Ursus maritimus) are subjected to several anthropogenic threats, climate warming and exposure to pollutants being two of these. For polar bears, one of the main effects of climate warming is limited access to prey, due to loss of their sea ...
Bjørn Munro Jenssen, Bjørn Munro Jenssen, Gro Dehli Villanger, Kristin Møller Gabrielsen, Jenny eBytingsvik, Thea Østergaard Bechshøft, Tomasz Maciej Ciesielski, Christian eSonne, Rune eDietz   +8 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Polar bear energetic and behavioral strategies on land with implications for surviving the ice-free period

Nature Communications
Declining Arctic sea ice is increasing polar bear land use. Polar bears on land are thought to minimize activity to conserve energy. Here, we measure the daily energy expenditure (DEE), diet, behavior, movement, and body composition changes of 20 ...
Anthony M. Pagano, Karyn D. Rode, Nicholas J. Lunn, David McGeachy, Stephen N. Atkinson, Sean D. Farley, Joy A. Erlenbach, Charles T. Robbins   +7 more
doaj   +1 more source