Results 51 to 60 of about 203,115 (295)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Differentially rotating force-free magnetosphere of an aligned rotator: analytical solutions in split-monopole approximation

, 2007
In this paper we consider stationary force-free magnetosphere of an aligned rotator when plasma in the open field line region rotates differentially due to presence of a zone with the accelerating electric field in the polar cap of pulsar.
A. N. Timokhin, Gruzinov
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

GPS TEC, scintillation and cycle slips observed at high latitudes during solar minimum [PDF]

Annales Geophysicae, 2010
High-latitude irregularities can impair the operation of GPS-based devices by causing fluctuations of GPS signal amplitude and phase, also known as scintillation.
P. Prikryl, P. T. Jayachandran, S. C. Mushini, D. Pokhotelov, J. W. MacDougall, E. Donovan, E. Spanswick, J.-P. St.-Maurice   +7 more
doaj   +1 more source

On the Origin of X-ray Emission From Millisecond Pulsars in 47 Tuc [PDF]

, 2003
The observed spectra and X-ray luminosities of millisecond pulsars in 47 Tuc can be interpreted in the context of theoretical models based on strong, small scale multipole fields on the neutron star surface.
Becker W., Becker W., Bhattacharya D., Bhattacharya D., Bisnovatyi-Kogan G. S., Blandford R. D., Harding A. K., Heggie D. C., Jones P. B., Jones P. B., K. S. Cheng, Konar S., Mineo T., Radhakrishnan V., Ronald E. Taam, Sakurai I., Schonberner D., Shalybkov D. A., Srinivasan G., Usov V. V.   +19 more
core   +3 more sources

Interhemispheric Survey of Polar Cap Aurora [PDF]

Journal of Geophysical Research: Space Physics, 2018
AbstractThis study investigates the interhemispheric nature of polar cap auroras via ultraviolet imaging, combined with particle data, to determine whether they occur on open or closed field lines. Data from the SSUSI (Special Sensor Ultraviolet Spectrographic Imager) instrument on board the DMSP (Defence Meteorological Satellite Program) spacecraft ...
J. A. Reidy, R. C. Fear, D. K. Whiter, B. Lanchester, A. J. Kavanagh, S. E. Milan, J. A. Carter, L. J. Paxton, Y. Zhang   +8 more
openaire   +4 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Charge Densities above Pulsar Polar Caps [PDF]

The Astrophysical Journal, 2000
A simplified model provided the framework for our investigation into the distribution of energy and charge densities above the polar caps of a rotating neutron star. We assumed a neutron star with m = 1.4M⊙, r = 10km, dipolar field |B0| = 1012G, B||Ω and Ω = 2Π · (0.5s)−1. The effects of general relativity were disregarded.
Jessner, A., Lesch, H., Kunzl, T.
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source