Results 81 to 90 of about 52,059 (298)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Combined effects of crude oil exposure and warming on eggs and larvae of an arctic forage fish

Scientific Reports, 2021
Climate change, along with environmental pollution, can act synergistically on an organism to amplify adverse effects of exposure. The Arctic is undergoing profound climatic change and an increase in human activity, resulting in a heightened risk of ...
Morgan Lizabeth Bender, Julia Giebichenstein, Ragnar N. Teisrud, Jennifer Laurent, Marianne Frantzen, James P. Meador, Lisbet Sørensen, Bjørn Henrik Hansen, Helena C. Reinardy, Benjamin Laurel, Jasmine Nahrgang   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Decline and northward shift in Arctic cod distribution associated with the changing climate around Greenland

Arctic Science
Arctic cod (Boreogadus saida Lepechin, 1774) is a key species in Arctic marine ecosystems, acting as a dominant mid-trophic link that transfers up to 75% of energy to higher trophic levels. It is therefore central to cultural identity, ecosystem function,
Teunis Jansen, Søren Post, Rikke Becker Jacobsen, Karl Michael Werner, Eva Friis Møller, Aqqalu Rosing-Asvid, AnnDorte Burmeister, Anna Burdenski, Mathane Qatsa, Caroline Bouchard   +9 more
doaj   +1 more source

Mixed Buchsbaum--Rim Multiplicities

, 1995
We prove the results about mixed Buchsbaum--Rim multiplicities announced in (9.10)(ii) on p.224 of our recent paper [J.Alg.(1994)], including a general mixed-multiplicity formula. In addition, we identify these multiplicities as the coefficients of the ``
Kleiman, Steven, Thorup, Anders
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Mesopelagic Sound Scattering Layers of the High Arctic: Seasonal Variations in Biomass, Species Assemblage, and Trophic Relationships

Frontiers in Marine Science, 2019
Mesopelagic sound scattering layers (SSL) are ubiquitous in all oceans. Pelagic organisms within the SSL play important roles as prey for higher trophic levels and in climate regulation through the biological carbon pump.
Maxime Geoffroy, Maxime Geoffroy, Malin Daase, Marine Cusa, Gérald Darnis, Martin Graeve, Néstor Santana Hernández, Jørgen Berge, Jørgen Berge, Paul E. Renaud, Paul E. Renaud, Finlo Cottier, Finlo Cottier, Stig Falk-Petersen, Stig Falk-Petersen   +14 more
doaj   +1 more source

Consequences of simulated microgravity in neural stem cells: biological effects and metabolic response. [PDF]

, 2015
Objective: Microgravity was often shown to cause cell damage and impair cell cycle in a variety of biological systems. Since the effects on the neural system were poorly investigated, we aimed to gain insight into how biological processes such as cell ...
ABBALLE, LUANA, ALFANO, VINCENZO, BEGALLI, FEDERICA, BESHARAT, ZEIN MERSINI, CAMPESE, Antonio Francesco, CASADEI, LUCA, CATANZARO, GIUSEPPINA, FERRETTI, ELISABETTA, MANETTI, Cesare, MIELE, EVELINA, NAPOLITANO, Maddalena, PO, AGNESE, SCREPANTI, Isabella, SILVANO, MARIANNA, VACCA, Alessandra, VALERIO, MARIACRISTINA   +15 more
core   +1 more source

A novel ACE inhibitory peptide from Gadus morhua skin: Isolation, characterization and antihypertensive mechanisms

Journal of Functional Foods
This study aimed to develop a novel ACE inhibitory peptide from cod skin with antihypertensive activity. Cod skin collagen hydrolysate was prepared by stepwise enzymatic hydrolysis using Collagen hydrolase followed by flavourzyme.
Shuai Li, Jie Huai, Bingfu Yang, Cunxi Lu, Junjie Qiu, Yi Ding, Renjie Zhou, Shan Wang   +7 more
doaj   +1 more source