Results 81 to 90 of about 130,570 (300)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Polar Coordinates: A Hard Area Problem [PDF]
, 2011 Educação Superior::Ciências Exatas e da Terra::MatemáticaThe resource is about a dynamic representation in which a ray moves along the curve r = 1 + cos θ describing the area of the region outlined by the curve, but outside the region outlined by the ...
Talman, Louis A.
core +2 more sources
Odessa Astronomical Publications, 2007 We present photometry of the asynchronous polar Nova Cygni 1975 = V1500 Cyg in 2005-2006. The brightness of star in R in the 2006 was increased on 0:53m in comparison with 2005.
A. A. Litvinchova +2 more
doaj +1 more source
Polar and cartesian curves (MathsCasts) [PDF]
, 2011 This recording explains the relationship between Polar and Cartesian coordinates of a 2D curve. An example is then given of converting a polar equation into Cartesian form and an example is given of converting a Cartesian equation into polar ...
Vida Weiss
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Polar Coordinates: A Hard Area Problem [PDF]
, 2016 Educação Superior::Ciências Exatas e da Terra::MatemáticaThe resource is about a dynamic representation in which a ray moves along the curve r = 1 + cos θ describing the area of the region outlined by the curve, but outside the region outlined by the ...
Talman, Louis A.
core +2 more sources
High-order involute modified noncircular bevel gears
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014 Noncircular bevel gears (NBGs) is a kind of spatial transmission mechanism which can be used to transmit the motion and power between two intersecting axes with a variable transmission ratio and according to a suitable motion program.
Jiqiang XIA, Kan SHI, Chunjie WANG
doaj +1 more source
The Fields of Moduli for Polarized Abelian Varieties and for Curves [PDF]
Nagoya Mathematical Journal, 1972 In the study of moduli of polarized abelian varieties and of curves as well as in the theory of complex multiplications, the notion of fields of moduli for structures plays an essential role. This notion was first introduced by Matsusaka [7] for polarized varieties with some pleasing properties and later was given a more comprehensible treatment by ...
openaire +3 more sources