Results 61 to 70 of about 61,418 (298)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Determination of Global Geodetic Parameters Using Satellite Laser Ranging Measurements to Sentinel-3 Satellites

open access: yesRemote Sensing, 2019
Sentinel-3A/3B (S3A/B) satellites are equipped with a number of precise instruments dedicated to the measurement of surface topography, sea and land surface temperatures and ocean and land surface color.
Dariusz Strugarek   +6 more
doaj   +1 more source

Origin of polar order in dense suspensions of phototactic micro-swimmers. [PDF]

open access: yesPLoS ONE, 2012
A main question for the study of collective motion in living organisms is the origin of orientational polar order, i.e., how organisms align and what are the benefits of such collective behaviour. In the case of micro-organisms swimming at a low Reynolds
Silvano Furlan   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Maintenance of the Arctic Ocean large-scale baroclinic structure by the M2 tide

open access: yes, 1994
A three-dimensional structure of the M2 tidal currents has been reproduced by mathematical modelling. The possibility of energy transfer from the tidal barotropic motion to large-scale baroclinic circulation of the Arctic Ocean has been estimated. It has
Polyakov, Igorv
core   +1 more source

Co-seismic Earth’s rotation change caused by the 2012 Sumatra earthquake

open access: yesGeodesy and Geodynamics, 2012
Earthquakes heavily deform the crust in the vicinity of the fault, which leads to mass redistribution in the earth interior. Then it will produce the change of the Earth’s rotation (polar motion and length of day) due to the change of Earth inertial ...
Xu Changyi, Sun Wenke
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The combination of polar motion observations [PDF]

open access: yesSymposium - International Astronomical Union, 1988
Polar motion data for the period 1981–1985 are used to obtain a combined solution from Doppler, Satellite Laser Ranging, and Astrometric observations. The combined solution is a weighted average of the three series, with weights determined from reported errors which are scaled so that they agree with errors estimated from differences among the various ...
Clark R. Wilson, R. O. Vicente
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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