Results 31 to 40 of about 14,054 (271)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Polar, Cluster and SuperDARN evidence for high latitude merging during southward IMF: temporal/spatial evolution [PDF]

, 2003
Magnetic merging on the dayside magnetopause often occurs at high latitudes. Polar measured fluxes of accelerated ions and wave Poynting vectors while skimming the subsolar magnetopause.
A. Balogh (7591361), K. D. Siebert (7592168), Weimer, D. R., J. D. Scudder (7592156), Dunlop, M., E. J. Lund (7592159), Russell, C. T., M. André (3683134), Dunlop, M. W., Rème, H., André, M., C. J. Farrugia (7592051), Burke, W. J., W. J. Burke, Lester, M., J. A. Wild, Grocott, A., M. Lester, W. J. Burke (7592153), N. C. Maynard, M. Andre, A. Balogh, M. Lester (7589660), E. J. Lund, C. T. Russell, Lund, E., H. Rème, Balogh, A., Maynard, N. C., Lund, E. J., C. T. Russell (7592162), M. Dunlop, Adrian Grocott (7590026), J. A. Wild (7591442), Ober, D. M., C. J. Farrugia, Siebert, K. D., A. Grocott, D. R. Weimer, D. M. Ober (7592150), K. D. Siebert, D. R. Weimer (7592165), M. W. Dunlop (7591493), Scudder, J. D., Farrugia, C. J., H. Rème (7591274), Wild, J. A., J. D. Scudder, D. M. Ober, N. C. Maynard (7592147)   +49 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Demonstration and Evaluation of 3D Winds Generated by Tracking Features in Moisture and Ozone Fields Derived from AIRS Sounding Retrievals

Remote Sensing, 2019
For more than 15 years, polar winds from the Moderate Resolution Imaging Spectroradiometer (MODIS) imagery have been generated by the National Oceanic and Atmospheric Administration (NOAA) and the Cooperative Institute for Meteorological Satellite ...
David Santek, Sharon Nebuda, Dave Stettner   +2 more
doaj   +1 more source

Getting around Antarctica: new high-resolution mappings of the grounded and freely-floating boundaries of the Antarctic ice sheet created for the International Polar Year [PDF]

, 2011
The boundary of grounded ice and the location of ice transitioning to a freely floating state are mapped at 15-m resolution around the entire continent of Antarctica.
Rotschkly, G., R. Drews, Corr, H., P. Vornberger, Fricker, Helen, Bindschadler, R., Brunt, K., R. Bingham, A. Wichlacz, Young, N., Bohlander, Jennifer, Wichlacz, Amy, L. Padman, Urbini, S., Padman, Laurie, Corr, Hugh, Bingham, Robert George, Vornberger, P., K. Brunt, Kohler, Jack, Rack, Wolfgang, Hall, M., Young, Neal, Kohler, J., Hindmarsh, Richard, Bindschadler, Robert, H. Choi, M. Hall, Fricker, H., Hindmarsh, R., Choi, Hyeungu, Hall, Monica, Brunt, Kelly, Choi, H., R. Bindschadler, Bohlander, J., Wichlacz, A., H. Fricker, N. Young, Vornberger, Patricia, Padman, L., Drews, R., H. Corr, Rack, W., W. Rack, S. Urbini, Urbini, Stefano, Rotschky, G., Bingham, B., Rotschky, Gerit, J. Bohlander, Drews, Reinhard, Bingham, R., R. Hindmarsh, J. Kohler, G. Rotschky   +55 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Prediction of earth rotation and polar motion

, 1981
Prepared for National Aeronautics and Space Administration, Goddard Space Flight Center, Greenbelt, Maryland: Grant No. NSG 5265, OSURF Project 711055Based on the analysis of the polar motion behavior, we found the possibility of predicting polar motion ...
Zhu, Sheng Yuan
core   +1 more source

Combined SAI-SHAO prediction of Earth Orientation Parameters since 2012 till 2017

Geodesy and Geodynamics, 2018
As the participants of Earth Orientation Parameters Combination of Prediction Pilot Project (EOPC PPP), Sternberg Astronomical Institute of Moscow State University (SAI) and Shanghai Astronomical Observatory (SHAO) have accumulated ∼1800 days of Earth ...
Leonid Zotov, Xueqing Xu, Yonghong Zhou, Arkadiy Skorobogatov   +3 more
doaj   +1 more source