Results 41 to 50 of about 2,970,939 (235)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Norway and past International Polar Years—a historical account

, 2007
Surveying Norway’s role in past International Polar Years (IPYs), this essay by historian Stian Bones contributes to a broader understanding of Norway as a “polar nation”. He describes the strengths of Norway’s scientific traditions in the polar regions,
Bones, Stian
core   +1 more source

Combined SAI-SHAO prediction of Earth Orientation Parameters since 2012 till 2017

Geodesy and Geodynamics, 2018
As the participants of Earth Orientation Parameters Combination of Prediction Pilot Project (EOPC PPP), Sternberg Astronomical Institute of Moscow State University (SAI) and Shanghai Astronomical Observatory (SHAO) have accumulated ∼1800 days of Earth ...
Leonid Zotov, Xueqing Xu, Yonghong Zhou, Arkadiy Skorobogatov   +3 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Guest editorial—the ballyhoo over polar bears

, 2009
Critics have said that there’s little or no justification for the focus that polar bears (Ursus maritimus) have received as a threatened species. Recent studies project dramatic reductions in polar bear numbers in just a few decades, in concert with the ...
Vongraven, Dag
core   +1 more source

Polar bear depredation of a thick-billed murre fledgling in open water at Prince Leopold Island, Nunavut

, 2022
Sea-ice distribution and duration are declining across the circumpolar range of the polar bear (Ursus maritimus), resulting in a reduced access to ice-obligate seals, its primary prey.
Di Corrado, Christopher, Franco, João, Obbard, Martyn E., Wise, Boris, Pimenta, Roger   +4 more
core   +1 more source

The application of a combination of weighted least-squares and autoregressive methods in predictions of polar motion parameters [PDF]

Acta Geodaetica et Geophysica, 2018
This study employs a combination of weighted least-squares extrapolation and an autoregressive model to produce medium-term predictions of polar motion (PM) parameters. The precisions of PM parameters extracted from earth orientation parameter (EOP) products are applied to determine the weight matrix. This study employs the EOP products released by the
Wu, Fei, Deng, Kazhong, Chang, Guobin, Wang, Qianxin   +3 more
openaire   +2 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source