Results 61 to 70 of about 1,088,783 (177)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

High Levels of Circularly Polarized Emission from the Radio Jet in NGC 1275 (3C 84)

, 2004
We present multi-frequency, high resolution VLBA circular polarization images of the radio source 3C 84 in the center of NGC 1275. Our images reveal a complex distribution of circular polarization in the inner parsec of the radio jet, with local levels ...
D. C. Homan, J. F. C. Wardle, Stickel M., Wardle J. F. C.   +3 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Polarization fluctuations due to extragalactic sources [PDF]

, 1999
We have derived the relationship between polarization and intensity fluctuations due to point sources. In the case of a Poisson distribution of a population with uniform evolution properties and constant polarization degree, polarization fluctuations are
Burigana, C., Ciliegi, P., Danese, L., De Zotti, G., Gruppioni, C.   +4 more
core   +2 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

One-step growth method of silver nanowires in aqueous environment

Materials Research Express, 2020
Silver nanowires were successfully prepared by one-step growth method in aqueous environment. The suitable pH value is a key factor for the successful preparation of silver nanowires.
Xiao-Li Liu, Shuo Han, Shou-Bao Zhang, Shao-Shuai Zhou, Na Jiao, Hong-Yan Zhao, Jianbo Li   +6 more
doaj   +1 more source

Polarization Aberrations in High-Numerical-Aperture Lens Systems and Their Effects on Vectorial-Information Sensing

Remote Sensing, 2022
The importance of polarization aberrations has been recognized and studied in numerous optical systems and related applications. It is known that polarization aberrations are particularly crucial in certain photogrammetry and microscopy techniques that ...
Yuanxing Shen, Binguo Chen, Chao He, Honghui He, Jun Guo, Jian Wu, Daniel S. Elson, Hui Ma   +7 more
doaj   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Identification of serous ovarian tumors based on polarization imaging and correlation analysis with clinicopathological features

Journal of Innovative Optical Health Sciences, 2023
Ovarian cancer is one of the most aggressive and heterogeneous female tumors in the world, and serous ovarian cancer (SOC) is of particular concern for being the leading cause of ovarian cancer death.
Yulu Huang, Anli Hou, Jing Wang, Yue Yao, Wenbin Miao, Xuewu Tian, Jiawen Yu, Cheng Li, Hui Ma, Yujuan Fan   +9 more
doaj   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source