Results 31 to 40 of about 5,766 (246)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Visible Light Broadband Achromatic Metalens Based on Variable Height Nanopillar Structures

Photonics
Metalenses have excellent modulation capabilities in terms of phase, amplitude, and polarization of light, significantly reducing the size and complexity of imaging systems, and showing great application prospects.
Yongyang Li, Haiyang Huang, Cong Zhang, Xiangshuo Shang, Yang Liu, Junyan Hu, Dengyu Shan, Naiyun Tang, Wei Li   +8 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Mapping grain boundary heterogeneity at the nanoscale in a positive temperature coefficient of resistivity ceramic

APL Materials, 2017
Despite being of wide commercial use in devices, the orders of magnitude increase in resistance that can be seen in some semiconducting BaTiO3-based ceramics, on heating through the Curie temperature (TC), is far from well understood.
Kristina M. Holsgrove, Demie M. Kepaptsoglou, Alan M. Douglas, Quentin M. Ramasse, Eric Prestat, Sarah J. Haigh, Michael B. Ward, Amit Kumar, J. Marty Gregg, Miryam Arredondo   +9 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Control of ferroelectric polarization in BiFeO3 bilayer films through interface engineering

npj Quantum Materials
Predetermining the as-grown polarization of ferroelectric thin films is essential to integrate their reliable properties into electronic devices.
Xiaokang Yao, Can Wang, Lei Liao, Xinyan Wang, Ning Liang, Tao Yan, Rui Wang, Meng He, Er-Jia Guo, Chen Ge, Lifen Wang, Xuedong Bai, Guozhen Yang, Kuijuan Jin   +13 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

High-efficiency RGB achromatic liquid crystal diffractive optical elements

Opto-Electronic Advances
Liquid crystal Pacharatnam-Berry phase optical elements (PBOEs) have found promising applications in augmented reality and virtual reality because of their slim formfactor, lightweight, and high optical efficiency. However, chromatic aberration remains a
Yuqiang Ding, Xiaojin Huang, Yongziyan Ma, Yan Li, Shin-Tson Wu   +4 more
doaj   +1 more source