ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Covalent Functionalization of NiFe Layered Double Hydroxides using Tris(Hydroxymethyl)Aminomethane
Small, EarlyView.Covalent functionalization of NiFe layered double hydroxides with tris(hydroxymethyl)aminomethane enables controlled growth, enhanced structural order, and improved processability. Temporary TRIS anchoring promotes stable water‐based inks and binder‐free electrode fabrication, leading to enhanced oxygen evolution activity and long‐term stability under ...
Alvaro Seijas Da Silva +8 more
wiley +1 more source
A Polarization-Multiplexed Multifunctional Metalens for Triple-Focus Coplanar Imaging. [PDF]
Nanomaterials (Basel)Lu H +6 more
europepmc +1 more source
VIEW, EarlyView.Ovarian cancer has been linked to the microbiome as a potential environmental contributor, but how this association relates to tumor progression remains unclear. By comparing tumor and nontumor tissues, we identified a severity‐associated microbial and metabolic signature and showed that probiotics can partially restore immune balance and slow tumor ...
Chanyuan Li +11 more
wiley +1 more source
High-capacity and secure inter-satellite optical wireless communication using 2D DPS-OCDMA. [PDF]
Sci RepArmghan A +5 more
europepmc +1 more source
Technology for Whom and for What? A Global South View of Tech Diplomacy
Global Policy, EarlyView.ABSTRACT International politics is linked to its technical‐social character. Also, technology is socially constructed and thereby not entirely neutral or impartial. A tech‐driven geopolitical landscape has been a defining feature of contemporary world politics.
Eugenio V. Garcia
wiley +1 more source
Ultra-wideband optical diffractive network for mode multiplexing across the entire telecommunication range. [PDF]
Nat CommunKong A +13 more
europepmc +1 more source
Norwegian Blues? Rethinking the Idea of Middle Powers in an Era of Fuzzy Bifurcation
Global Policy, EarlyView.ABSTRACT Unsuccessful efforts to update the middle power concept for the contemporary international system have prompted calls for the concept to be “historicized”—to be retired from common use and treated as a purely historical term. The problem with this proposal is that “middle power” has become increasingly popular in the 2020s in analysis ...
Kim Richard Nossal
wiley +1 more source
Recent Advances in Ultra-Weak Fiber Bragg Gratings Array for High-Performance Distributed Acoustic Sensing (Invited). [PDF]
Sensors (Basel)Wang Y +8 more
europepmc +1 more source
Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy
Allergy, EarlyView.We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt +7 more
wiley +1 more source