Results 71 to 80 of about 176,138 (300)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Polarization-Insensitive Silicon Photonic Variable Optical Attenuator

Photonics
We propose and demonstrate a polarization-insensitive silicon photonic variable optical attenuator. The designed device uses a two-dimensional apodized grating coupler as a surface-normal coupling interface, which has the advantages of low-cost fiber ...
Meixin Li, Yuxuan Zhang, Hao Jiang, Haoran Wang, Danni Luo, Jing Yang, Yabin Li, Zanyun Zhang   +7 more
doaj   +1 more source

Broadband Polarization-Independent Directional Coupler Using Asymmetric-Waveguides

IEEE Photonics Journal, 2019
A high-performance broadband polarization-independent directional coupler is designed by using asymmetric-waveguides configuration on a silicon-on-insulator platform.
Qinghuan Xu, Jifang Tao, Chonglei Sun, Jia Zhao, Zuojia Wang, Liuge Du, Xun Li   +6 more
doaj   +1 more source

Non-orthogonal polarization multiplexed metasurfaces for tri-channel polychromatic image displays and information encryption

Nanophotonics, 2021
Interference usually occurs between two non-orthogonally polarized light beams. Hence, metasurface enabled polarization multiplexing is generally conducted under two orthogonal polarization states to realize independent intensity and/or phase modulations.
Ren Renyuan, Li Zile, Deng Liangui, Shan Xin, Dai Qi, Guan Zhiqiang, Zheng Guoxing, Yu Shaohua   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Synthesis of metasurface-enabled broadband polarization-independent light structuring

Structured light beams have attracted significant interest due to their versatile spatial or spatiotemporal configurations, which can potentially transform various real-world applications not achievable using conventional Gaussian beams.
Mehmood, Muhammad Qasim, Tauqeer, Tauseef, Butt, Naureen, Mahmood, Nasir   +3 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Photoelectron spin polarization approaching unity: photoionization of TI

, 1990
Böwering N, Salzmann M, Müller M, Klausing H-W, Heinzmann U. Photoelectron spin polarization approaching unity: photoionization of TI. Physica Scripta. 1990;41(4):429-432.It is shown that a complete photoelectron-spin polarization occurs independent of ...
Klausing, H.-W., Salzmann, M., Müller, M., Böwering, N., Heinzmann, Ulrich   +4 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Hybrid-Plasmonic-Waveguide-Based Polarization-Independent Directional Coupler

IEEE Access, 2020
In optical interconnection field, inconsistent coupling behaviors of TE and TM modes may cause abnormal operation. Therefore, it is very significant to implement a polarization-independent directional coupler.
Li Zhang, Can Pan, Dezheng Zeng, Yanzhao Yang, Yatao Yang, Junxian Ma   +5 more
doaj   +1 more source