Results 81 to 90 of about 176,138 (300)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Polarization-Insensitive Lithium Niobate-on-Insulator Interferometer

Micromachines
The key components of a polarization-independent electro-optic (EO) interferometer, including the beam splitter, mode converter, and directional coupler, are designed based on a lithium niobate (LN) platform on an integrated insulator to ensure high ...
Jiali Liao, Linke Liu, Yanling Sun, Zihao Wang, Wei Li, Jinrong Lan, Lin Ma, Zhenzhong Lu   +7 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Polarization-independent vertical coupler for photonics integration

Optics Express, 2004
We present the first systematic design approach for compact polarization-independent mode-size transformers based on tapered resonant vertical couplers with transfer efficiencies greater than 90%. Resonant coupling occurs at a critical taper width having equal TE and TM effective index. Being polarization-independent broadens the usefulness of vertical
Mee-Koy, Chin, Chee-Wei, Lee, Jinyuan, Shen   +2 more
openaire   +2 more sources

Analysis of Polarization Independent Diffused QW Optical Amplifiers [PDF]

, 2003
The features of polarization independence of optical amplifiers achieved by using diffused QW are discussed. Our theoretical results successfully explain why polarization independence can achieve in the long wavelength tail of the modal gain and ...
Choy, WCH
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Plasmonics metalens independent from the incident polarizations

Optics Express, 2015
An ultra-thin, planar, broadband metalens composed of L-shaped gap antennas on a thin gold film has been designed, which is suitable for both circular and X/Y linear polarizations focusing simultaneously. The phase discontinuity of the cross-polarized transmisson light can be manipulated by the length and width of the L-shaped gap antenna accurately ...
Wei, Wang, Zhongyi, Guo, Rongzhen, Li, Jingran, Zhang, Yan, Li, Yi, Liu, Xinshun, Wang, Shiliang, Qu   +7 more
openaire   +2 more sources

Polarization-Independent Phase-Sensitive Amplification

, 2016
We thoroughly analyze the requirements on the signal and idler state of polarizations (SOPs) for achieving maximum amplification in phase-sensitive amplifiers (PSAs).
Karlsson, Magnus, Lorences Riesgo, Abel, Andrekson, Peter   +2 more
core   +1 more source

Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke, Petra Steinacker, Steffen Halbgebauer, Patrick Oeckl, Geert Mayer, Markus Otto   +5 more
wiley   +1 more source

Independent spatial intensity, phase and polarization distributions

Optics Express, 2013
Independent control of the spatial intensity, phase and polarization distribution has numerous applications in direct laser writing, microscopy and optical trapping. Especially, it is well known that the inversion of the Debye-Wolf diffraction integral usually leads to spatially varying intensity, phase and polarization maps.
Erik H, Waller, Georg, von Freymann
openaire   +2 more sources