Results 61 to 70 of about 142,775 (314)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Designing Customized EBSD Software: Inverse Pole Figure Mapping of Crystal Orientations Using Finite Element Shape Functions

Designs
Inverse pole figure mapping is a common orientation visualization method used in electron backscatter diffraction (EBSD) software to display crystal orientations.
Youliang He
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analisis Orientation Distribution Function (ODF) Unsur Nb dan Senyawa Intermetalik Superkonduktor Nb3Sn

Jurnal Teknik ITS, 2013
Perkembangan tekstur pada bahan polikristal memngkinkan peningkatan sifat fisik bahan, diantaranya superkonduktivitas. Penelitian ini menggunakan pelet Nb-Sn hasil metalurgi serbuk dengan dan tanpa sintering.
Kholifatul Aniswatin, Doty Dewi Risanti, Andika Widya Pramono   +2 more
doaj  

Texture analysis of deformation induced martensite in an AISI 301L stainless steel: microtexture and macrotexture aspects

Materials Research, 2009
Experiments have been conducted to study the strain induced transformation from austenite to martensite in a metastable AISI 301LN austenitic stainless steel, deformed by uniaxial tension applied along rolling direction.
Hamilton Ferreira Gomes de Abreu, Marcelo José Gomes da Silva, Luís Flávio Gaspar Herculano, Harry Bhadeshia   +3 more
doaj   +1 more source

Quantifying the Relationship Between the Medial Patellofemoral Complex and Patellar Borders: A Pediatric Cadaveric Study

Orthopaedic Journal of Sports Medicine, 2022
Background: The medial patellofemoral complex (MPFC) is comprised of the medial quadriceps tendon-femoral ligament (MQTFL) superiorly and the medial patellofemoral ligament (MPFL) inferiorly.
Danika Baskar BA, Tyler Stavinoha MD, Matthew Rohde BS, Marc Tompkins, Theodore J. Ganley MD, Henry B. Ellis MD, Philip L. Wilson MD, Daniel W. Green MD, MS, Nicole Segovia BS, Kevin G. Shea MD   +9 more
doaj   +1 more source

Piezoelectric Pole Figure of a Vein Quartz Sample [PDF]

Texture, Stress, and Microstructure, 1988
Longitudinal piezoelectric coefficients have been measured on cubic samples and from 150 different orientations on a spherical sample of coarse‐grained vein quartz. The results are consistent with the presence of a piezoelectric fabric. The piezoelectric pole figure of the studied spherical sample demonstrates three distinct patterns of alternatively ...
M. M. Ghomshei, B. B. Narod, T. L. Templeton, A. S. Arrott, R. D. Russell   +4 more
openaire   +1 more source

RHEED Pole Figure Measurements of Biaxial Thin Film Growth Front Evolution

, 2011
The most frequently used characterization technique for biaxial texture formation in thin films is x-ray pole figure analysis. However, x-rays interact weakly with matter and can penetrate a few microns deep into the film.
Churamani Gaire, Wen Yuan, Gwo-Ching Wang, Toh-Ming Lu, Yu Liu   +4 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Totem pole

, 1950
A lone totem pole figure holding a bow and arrow with an owl between it's legs.A lone totem pole figure holding a bow and arrow with an owl between it's ...

core   +1 more source