Results 51 to 60 of about 79,918 (267)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Одна країна – декілька національностей: етнічний склад населення Польщі в історичній ретроспективі

Простір в історичних дослідженнях, 2020
Польща завжди була багатонаціональною країною. На польських землях від Середньовіччя до сьогодні поляки та представники різних націй жили та функціонували, взаємодіючи між собою, і здебільшого намагалися співіснувати в гармонії.
Мареш Тереза
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Parcelling of the lands of Eastern Galicia in the second half of the 19th – early 20th century

Вестник Тамбовского университета. Серия: Гуманитарные науки
Importance. The economic development of Austro-Ugric Russia in the second half of the 19th – early 20th century was catching up with other regions of the Habsburg monarchy.
R. M. Zhitin, A. G. Topilsky
doaj   +1 more source

Троянская война ассирийцев: редкое обозначение турецко-татарских войск в похвале Яну III Собескому / Trojan War and the Assyrian People: Rare Designation of Turkish-Tatar Troops in Praise of Jan III Sobieski

Материалы по археологии и истории античного и средневекового Причерноморья, 2020
Glorifying the Military Exploits of the Newly Elected Polish King, the Authors of the “Praise” addressed to him, which was Later Translated into Russian, tied the Pole-defeated Detachments of the “Infidel” Turks and Crimean Tatars to People from the ...
Bogatyrev A.V.
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Self-identification of the Belarusian-speaking Population of the Grodno Region and its Surroundings in Previous Centuries and of the Sokółka Region Today

Acta Albaruthenica
The aim of this article is to describe the historical and modern ethnonyms of the Belarusian-speaking population in the Grodno region and to investigate whether and how much they have changed.
Mateusz Jan Kwiatkowski
doaj   +1 more source

CONTRIBUTIONS ON OPTIMIZING THE LEARNING OF SPECIFIC CONTENTS OF THE VIth GRADE HANDBALL GAME [PDF]

Annals of the “Ştefan cel Mare” University: Physical Education and Sport Section - The Science and Art of Movement, 2020
In the physical education class, handball appears as a sports game, being practiced by both girls and boys, its popularity being equal among students. Due to the fact that it is an accessible game, regarding the materials and work surface, handball is
Ursachi Ionel, Leuciuc Florin
doaj  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source