Re-considering Agri-Environmental Schemes premiums: the impact of fixed costs in sign-up decisions [PDF]
Current EU legislation states that premiums for agri-environmental schemes must be calculated based on forgone profit and additional costs. This approach has been implemented for the last decades without much success in farmer uptake, a situation that ...
Barreiro-Hurle, Jesus +2 more
core +1 more source
Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”
Advanced Science, EarlyView.This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner +3 more
wiley +1 more source
Finding the Right Balance: Challenges in Optimising the Promise of Complexity Research for NCD Best-Buys Implementation and Adoption Comment on "Barriers and Opportunities for WHO 'Best Buys' Non-communicable Disease Policy Adoption and Implementation From a Political Economy Perspective: A Complexity Systematic Review". [PDF]
Int J Health Policy ManagHebbar PB, Bhojani UM, Srinivas PN.
europepmc +1 more source
Changes in rapid HIV treatment initiation after national "treat all" policy adoption in 6 sub-Saharan African countries: Regression discontinuity analysis. [PDF]
PLoS Med, 2019 Tymejczyk O +16 more
europepmc +1 more source
Factors Influencing and Steps Leading to the Adoption of Best Management Practices by Louisiana Dairy Farmers [PDF]
A logistic regression procedure was used to assess the impact of socioeconomic attributes on the best management practices (BMPs) adoption decision by Louisiana dairy farmers relative to cost-share and fixed incentive payments.
Gauthier, Wayne M. +3 more
core +1 more source
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Robust research tools shed light on the crucial development issue of alcohol harm and enable effective policy adoption. [PDF]
Drug Alcohol Rev, 2018 Lecours N, Hallen G.
europepmc +1 more source
Advanced Science, EarlyView.This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang +10 more
wiley +1 more source
Scalable policy adoption and sustainable implementation of surgical care in the Americas. [PDF]
Rev Panam Salud PublicaKumar N +20 more
europepmc +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source