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Composition of poliovirus fibrils [PDF]
Archiv f�r die gesamte Virusforschung, 1973 Poliovirus radioactively labeled in its RNA and protein components was treated with various combinations of temperature, pH and sodium dodecyl sulphate (SDS) or with concentrated urea in order to induce the formation of fibrils. These were purified and their labeling was studied. In all cases the fibrils contained RNA and protein precursors.
Albert Boeye +2 more
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Poliovirus Infection in Guatemala
The American Journal of Tropical Medicine and Hygiene, 1960Summary The objective of the present study was to determine the frequency of poliovirus infection in Guatemala, primarily the inapparent infections occurring there. Sero-immunity, as indicated by serum neutralization tests in HeLa cell cultures, was demonstrated to all three poliovirus types.
Nevin S. Scrimshaw +2 more
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Denaturation of poliovirus procapsids
Archives of Virology, 1989The denaturation of poliovirus procapsids at pH 6.5 was studied, both in the frozen and liquid condition. Denaturation involved alteration of antigenic and physical features (isoelectric pH, alkali dissociability, sedimentation coefficient). Magnesium was a stabilizing factor, and the sedimentation coefficient was the most denaturation-sensitive ...
Rombaut, Bartholomeus +2 more
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Virologie (Montrouge, France), 2006
Poliovirus is the causal agent of paralytic poliomyelitis. Flaccid paralysis characteritic of poliomyelitis result from the destruction of motor neurons, the specific target cells of poliovirus in the central nervous system (CNS). The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be ...
Florence Colbère-Garapin +6 more
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Poliovirus is the causal agent of paralytic poliomyelitis. Flaccid paralysis characteritic of poliomyelitis result from the destruction of motor neurons, the specific target cells of poliovirus in the central nervous system (CNS). The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be ...
Florence Colbère-Garapin +6 more
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Nature, 1966
VARIATION in the chemical properties of the protein coat of different strains has been used as a marker test in investigations of the genetics of polioviruses. Bengtsson, Philipson, Persson and Laurent1 recently showed that a group of these tests had a common basis.
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VARIATION in the chemical properties of the protein coat of different strains has been used as a marker test in investigations of the genetics of polioviruses. Bengtsson, Philipson, Persson and Laurent1 recently showed that a group of these tests had a common basis.
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2016
Poliomyelitis (“polio”) is a disease caused by poliovirus, a small, nonenveloped icosahedral virus transmitted through the fecal–oral route. Three poliovirus subtypes exist: type 1, 2, and 3. Following a major viremia, poliovirus replicates within and can cause temporary or permanent damage to the central nervous system, predominantly to the brain stem
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Poliomyelitis (“polio”) is a disease caused by poliovirus, a small, nonenveloped icosahedral virus transmitted through the fecal–oral route. Three poliovirus subtypes exist: type 1, 2, and 3. Following a major viremia, poliovirus replicates within and can cause temporary or permanent damage to the central nervous system, predominantly to the brain stem
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Immunoelectrophoresis of poliovirus antigens [PDF]
Archiv f�r die gesamte Virusforschung, 1971 The electrophoretic migration of the antigens of six poliovirus strains was studied by immunoelectrophoresis in agarose gel at pH 8.2 and pH 7.0. Differences in migration were observed: the H antigens migrated faster than the corresponding N antigens.
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1992
Publisher Summary Poliovirus is a member of the Picornaviridae, a family of viruses that contains many different human and animal pathogens. Polioviruses occur in three serotypes, each of which can cause paralytic disease. The virus capsid is comprised of 60 copies each of four viral proteins; VP1 to VP4, arranged in icosahedral symmetry.
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Publisher Summary Poliovirus is a member of the Picornaviridae, a family of viruses that contains many different human and animal pathogens. Polioviruses occur in three serotypes, each of which can cause paralytic disease. The virus capsid is comprised of 60 copies each of four viral proteins; VP1 to VP4, arranged in icosahedral symmetry.
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Purification and Properties of Poliovirus
1959Publisher Summary This chapter attempts to purify, identify, and characterize poliovirus particles with respect to their physical, chemical, and serological properties. Polioviruses of human origin are considered that are classified immunologically as Types 1, 2, and 3.
Carlton E. Schwerdt +1 more
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Stabilisation of poliovirus with pirodavir.
Developments in biological standardization, 1995Two hundred and forty pyridazinamine derivates were assayed for their ability to stabilize the Oral Polio Vaccine (OPV). Of these, pirodavir (R 77975) was selected for vaccine potency tests. Although pirodavir turned out to be an effective stabilizer of OPV, the protection induced by pirodavir was not better, nor additive to the effect by MgCl2 1 M ...
Rombaut, Bartholomeus +2 more
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