Results 41 to 50 of about 86,994 (300)

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

International Journal of Infectious Diseases, 2019
This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut.
Merav Weil, Galia Rahav, Raz Somech, Tali Stauber, Jacqueline Alfandari, Leah Weiss, Ilana Silberstein, Victoria Indenbaum, Itay Bar Or, Ella Mendelson, Danit Sofer, Lester M. Shulman   +11 more
doaj   +1 more source

Poliovirus Vaccination Induces a Humoral Immune Response That Cross Reacts With SARS-CoV-2

Frontiers in Medicine, 2021
Background: Millions have been exposed to SARS-CoV-2, but the severity of resultant infections has varied among adults and children, with adults presenting more serious symptomatic cases.
Brittany A. Comunale, Lilly Engineer, Lilly Engineer, Yong Jiang, John C. Andrews, Qianna Liu, Lyuqing Ji, James T. Yurkovich, Roderick A. Comunale, Qiyi Xie   +9 more
doaj   +1 more source

A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]

, 2017
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel, Delgui, Laura Ruth   +1 more
core   +2 more sources

Vaccine-related poliovirus shedding in trivalent polio vaccine and human immunodeficiency virus status: analysis from under five children

BMC Research Notes, 2017
Background Poliomyelitis is an acute viral infection caused by poliovirus and transmitted via the fecal–oral route. The causative agent is one of the three serotypes of poliovirus (serotypes 1, 2, 3) that differ slightly in capsid protein.
Joanne Hassan, Laura Wangai, Peter Borus, Christopher Khayeka–Wandabwa, Lucy Wanja Karani, Mercy Kithinji, Michael Kiptoo   +6 more
doaj   +1 more source

Type 2 poliovirus detection after global withdrawal of trivalent oral vaccine

New England Journal of Medicine, 2018
BACKGROUND Mass campaigns with oral poliovirus vaccine (OPV) have brought the world close to the eradication of wild poliovirus. However, to complete eradication, OPV must itself be withdrawn to prevent outbreaks of vaccine‐derived poliovirus (VDPV ...
I. Blake, M. Pons-Salort, N. Molodecky, O. Diop, P. Chenoweth, A. Bandyopadhyay, M. Zaffran, R. Sutter, N. Grassly   +8 more
semanticscholar   +1 more source

Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. [PDF]

, 2010
The hnRNP C heterotetramer [(C1(3))C2] binds RNA polymerase II transcripts in the nucleus, along with other proteins of the core hnRNP complex, and plays an important role in mRNA biogenesis and transport.
Brunner, Jo Ellen, Ertel, Kenneth J, Rozovics, Janet M, Semler, Bert L   +3 more
core   +1 more source

Vaccine innovation, translational research and the management of knowledge accumulation [PDF]

, 2012
What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving ...
Andre, Archibugi, Aston, Baird, Baldwin, Bastien, Benison, Bentrup, Blume, Blume, Blume, Blume, Blume, Blume, Bodian, Bonu, Bryder, Burnet, Buse, Carter, Chase, Chataway, Connor, Constant, de Souza, Dosi, Douglas, Esparza, Feinberg, Fleck, Fujimura, Galambos, Gallagher, Garber, Gerschenkron, Girard, Griffin, Hacking, Hilleman, Hopkins, Hopkins, Hortsmann, IAVI, IOM, Kremer, Lanjouw, Marincola, Markel, Mays, McCoy, Mullan, Nelson, Nelson, Nichter, Nightingale, Nightingale, NIH, Ohid Yaqub, Ohka, Oshinsky, Paul, Paul Nightingale, Plotkin, Poltorak, Pérez-Cuevas, Racaniello, Rasti, Ren, Ridley, Robbins, Rogers, Rose, Rosenberg, Sabin, Schofield, Smith, Smith, Time, Time, Tomes, van Lente, Vernick, Vincenti, Weiss, West, Yaqub, Zinkernagel   +86 more
core   +2 more sources

Three-dimensional structure of poliovirus receptor bound to poliovirus [PDF]

Proceedings of the National Academy of Sciences, 2000
Poliovirus initiates infection by binding to its cellular receptor (Pvr). We have studied this interaction by using cryoelectron microscopy to determine the structure, at 21-Å resolution, of poliovirus complexed with a soluble form of its receptor (sPvr). This density map aided construction of a homology-based model of sPvr and, in conjunction with the
Harmon J. Zuccola, Alasdair C. Steven, David J. Filman, James M. Hogle, Vincent R. Racaniello, Brian M. McDermott, Naiqian Cheng, Benes L. Trus, David M. Belnap   +8 more
openaire   +3 more sources

Antiviral Development for the Polio Endgame: Current Progress and Future Directions

Pathogens
As the world is approaching the eradication of wild poliovirus serotype 1, the last of the three wild types, the question of how to maintain a polio-free world becomes imminent.
Hang Xie, Eric E. Rhoden, Hong-Mei Liu, Folake Ogunsemowo, Bernardo A. Mainou, Rachel M. Burke, Cara C. Burns   +6 more
doaj   +1 more source

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]

, 2014
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, Nicky J., Evans, David J., Simmonds, Peter, Witteveldt, Jeroen   +3 more
core   +2 more sources