Results 41 to 50 of about 1,384,523 (287)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Female Genital Mutilation (FGM/C) in Garissa and Isiolo, Kenya: Impacts on Education and Livelihoods in the Context of Cultural Norms and Food Insecurity

Societies
This article explores the complex challenges of combating Female Genital Mutilation (FGM) in the counties of Garissa and Isiolo (Kenya) amidst environmental stressors, particularly drought and food insecurity.
Ottis Mubaiwa, Donah Chilo
doaj   +1 more source

Queer in Cyprus? The LGBTIQ Movement, Normativity, and Resistance in a Changing (Trans)national Landscape

Social Sciences, 2023
The literature on lesbian, gay, bisexual, trans*, intersex, and queer (LGBTIQ) politics has established the interplay between domestic and transnational norms and political tactics.
Nayia Kamenou
doaj   +1 more source

Menorah Review (No. 65, Summer/Fall, 2006) [PDF]

, 2006
A Rebbe in Skirts -- By Way of Introduction: Reflections on Israeli Women\u27s Studies: A Reader -- Israeli Literature and Israeli Politics -- More in than Out -- Revisiting Old Themes Through a Contemporary Lens -- The World of Rabbi Nathan ...

core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Is political marketing new words or new practice in UK politics? [PDF]

, 2004
This review of the literature on political marketing and the party most associated with it in the UK, New Labour, suggests that the relationship is not straightforward. Politicians are, for example, hesitant to use marketing language in public.
Moloney, Kevin
core  

Dissemination of management into politics: Michael Porter and the political uses of management consulting [PDF]

, 2010
The article contributes to the literature on management dissemination by looking at how management fashions are diffused into and circulated in politics. The ideas of management have been increasingly disseminated into the realm of politics during recent
Kantola, Anu, Seeck, Hannele
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Reissues, Rewrites and Political Practice: Rodolfo Walsh in 1973

Iberoamericana. América Latina - España - Portugal, 2019
In 1973, Rodolfo Walsh finishes Operación masacre, a written text, edited several times, rewritten, corrected and completed over seventeen years; publishes Un oscuro día de justicia, a story from 1967; and edits Caso Satanowsky, an investigation from ...
Sylvia Saítta
doaj   +1 more source