Results 51 to 60 of about 1,096,453 (298)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

What Are Pluriversal Politics and Ontological Designing?. Interview with Arturo Escobar

DIID, 2022
What is ontological design, and how do we define Pluriversal politics? In this long interview, Arturo Escobar describes the fundamental shifts in contemporary social theory placing life at the center of his scholarly inquiry.
Arturo Escobar, Stefano Maffei
doaj   +1 more source

Do Campaign Contribution Limits Curb the Influence of Money in Politics? [PDF]

, 2020
Over 40% of countries around the world have adopted limits on campaign contributions to curb the influence of money in politics. Yet, we have limited knowledge on whether and how these limits achieve this goal. With a regression discontinuity design that
Gulzar, Saad, Rueda, Miguel R, Ruiz, Nelson A   +2 more
core   +1 more source

The design of social and political research [PDF]

Chinese Political Science Review, 2008
Good social and political research requires an explicit design. In this article, this is illustrated by a cycle of choices that begin with the transformation of an idea into a topic and end with the drawing of inferences from the patterns of association one finds. In between lie critical decisions about concepts, hypotheses, indicators, case selection,
openaire   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Towards an Ecology of Surveillance

DIID
In this paper I discuss the necessity to overcome the image of Big Brother in addressing surveillance issues through design practice. The idea of an ecological approach to surveillance, with references to the society of control (Deleuze, 1992), the ...
Andrea Facchetti
doaj   +1 more source

How Intense Policy Demanders Shape Postreform Politics: Evidence from the Affordable Care Act [PDF]

, 2018
The implementation of the Affordable Care Act (ACA) has been a politically volatile process. The ACA\u27s institutional design and delayed feedback effects created a window of opportunity for its partisan opponents to launch challenges at both the ...
AFP (Americans for Prosperity), Alberta, Bade, Bade, Bagley, Bawn, Beaussier, Berry, Bloch Rubin, Broockman, Béland, Béland, Béland, Béland, Campbell, CBO (Congressional Budget Office), Collier, DiSalvo, Downs, Fenno, George, Gerber, Gerring, Hacker, Haeder, Haeder, Haeder, Haeder, Hall, Harrington, Hertel-Fernandez, Hertel-Fernandez, Hertel-Fernandez, Herzenshorn, Himelfarb, Jacobs, Jacobs, Jones, Kelly, Lazarus, Lee, Levin, Mahoney, Maltzman, Mettler, Needham, Oberlander, Oberlander, Orren, Patashnik, Patashnik, Philip Rocco, Pierson, Poole, Rocca, Rocco, Rose, Roy, Schiller, Simon F. Haeder, Skocpol, Tomz, Weir, Woon   +63 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Architectures of Politics

Diseña, 2018
This article discusses the role of parliaments in the production of modern politics and proposes that contemporary political challenges necessitate a new parliamentarian architecture.
Ignacio Farías, Gonzalo Correa
doaj   +9 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source