Results 101 to 110 of about 34,837 (217)

Helix versus coil polypeptide macromers: gel networks with decoupled stiffness and permeability [PDF]

, 2012
As a platform for investigating the individual effects of substrate stiffness, permeability, and ligand density on cellular behavior, we developed a set of hydrogels with stiffness tuned by polymer backbone rigidity, independent of cross-link density and
Griffith, Linda G., Hammond, Paula T., Morey, Shannon M., Oelker, Abigail M.   +3 more
core   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Metabolic Engineering of Bacillus subtilis for the Production of Poly-γ-glutamic Acid from Glycerol Feedstock

Fermentation
Poly-γ-glutamic acid (γ-PGA) is an attractive biopolymer for medical, agri-food, and environmental applications. Although microbial synthesis by Bacilli fed on waste streams has been widely adopted, the obtainment of efficient sustainable production ...
L. Pasotti, Ilaria Massaiu, P. Magni, C. Calvio   +3 more
semanticscholar   +1 more source

New Sol-Gel Derived Bioactive Glasses and Organic/Inorganic Hybrids for Bone Regeneration

, 2011
Sol-gel derived bioactive glasses have been considered as one of the most promising materials for bone regeneration. However they are brittle, therefore composites are needed if bioactive materials are to share load with bone. One strategy for production
Yu, Bobo, Yu, Bobo
core   +1 more source

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Aerogel Scaffolds: Breathing Life Into Tissue Repair and Companion Diagnostics

Aggregate, Volume 7, Issue 3, March 2026.
Aerogel scaffolds are emerging as multifunctional biomedical platforms that bridge regenerative engineering and molecular diagnostics. By integrating hierarchical porosity, tunable mechanics, and programmable surface chemistry, aerogels can simultaneously support tissue reconstruction and enable localized biomarker sampling and signal transduction ...
Hanlin Zhang, Ruixuan Zheng, Jing Lin, Jiawu Weng, Lexiang Zhang, Fangfu Ye   +5 more
wiley   +1 more source

MXene‐Based Functional Platforms for Diabetes Prevention and Treatment

Carbon Neutralization, Volume 5, Issue 2, March 2026.
MXenes have been applied to antidiabetic treatment (wound treatment, glucose monitoring, and treatment of complications) with the representative work. ABSTRACT In recent years, a class of 2D transition metal carbides, nitrides, and carbonitrides (MXenes) has demonstrated outstanding advantages in the field of diabetes treatment, particularly in ...
Zixuan Wang, Yuhua Wang, Haijun Zhang, Yumei Wang, Jingwen Liu, Xinghui Liu   +5 more
wiley   +1 more source

A New Perspective in Nanocellulose‐Based Materials for Biomineralization and Strategies for Bone Repair

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
Nanocellulose‐based materials platform with the implementation of different bioactivation strategies for its potential use in hard tissue engineering (bone, tooth and cartilage). ABSTRACT Repairing large bone defects is a significant clinical challenge.
Jonathan Michel Barba Godinez, Ernesto Tinajero‐Díaz, Maria Soledad Peresin, Zaira Yunuen García Carvajal, Diego Gomez‐Maldonado   +4 more
wiley   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Poly(γ-glutamic acid)-coated lipoplexes loaded with Doxorubicin for enhancing the antitumor activity against liver tumors

Nanoscale Research Letters, 2017
The study was to develop poly-γ-glutamic acid (γ-PGA)-coated Doxorubicin (Dox) lipoplexes that enhance the antitumor activity against liver tumors. γ-PGA-coated lipoplexes were performed by electrostatistically attracting to the surface of cationic ...
Na Qi, Bo Tang, Guang Liu, Xingsi Liang
doaj   +1 more source