Results 71 to 80 of about 34,837 (217)

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Polypeptide-grafted macroporous polyHIPE by surface-initiated N-Carboxyanhydride (NCA) polymerization as a platform for bioconjugation [PDF]

, 2012
A new class of functional macroporous monoliths from polymerized high internal phase emulsion (polyHIPE) with tunable surface functional groups was developed by direct polypeptide surface grafting.
Andreas Heise, Audouin F., Audouin F., Barbetta A., Barbetta A., Barbetta A., Barbetta A., Barbetta A., Barbetta A., Barbey R., Blout E. R., Borase T., Brendan O’Connor, Brunauer S., Busby W., Cameron N. R., Cameron N. R., Carlsen A., Carnachan R. J., Cormack B. P., Cummins D., Cummins D., Deleuze H., Deming T. J., Dimitrov I., Engler A. C., Fabrice Audouin, Fernandez-Trillo F., Gibson M. I., Gokmen M. T., Habraken G. J. M., Habraken G. J. M., Habraken G. J. M., Hadjichristidis N., Hainey P., Heim R., Huang J., Jerabek K., Jin Huang, Kimmins S. D., Klok H.-A., Kovacic S., Krajnc P., Krajnc P., Kricheldorf H. R., Leber N., Livshin S., Lovelady E., Lu H., Lucchesi C., Mary Fox, Moglia R. S., Moine L., Orndorff W. R., Paul Clarke, Pierre S. J., Pulko I., Ruth Larragy, Schlaad H., Schwab M. G., Su F., Subramanian G., Sun J., Tang H., Tsien R., Tunc Y., Youssef C.   +66 more
core   +1 more source

Real‐time quality and safety monitoring of fruit juice using paper‐based platform

Food Biomacromolecules, EarlyView.
Schematic illustration of a paper‐based biosensor for rapid detection of fruit juice spoilage. Abstract Food spoilage and safety concerns still remain critically challenging within the fruit juice industry, especially as conventional detection methods, though precise, are often too time‐consuming, costly, and reliant on centralized laboratories.
Priti Das, Srushti Bhoite, Noopur Patil, Shubhro Chakrabartty, Debjani Dutta   +4 more
wiley   +1 more source

Preparation, Characterization and Properties of Alginate/Poly(γ-glutamic acid) Composite Microparticles

Marine Drugs, 2017
Alginate (Alg) is a renewable polymer with excellent hemostatic properties and biocapability and is widely used for hemostatic wound dressing. However, the swelling properties of alginate-based wound dressings need to be promoted to meet the requirements
Zongrui Tong, Yu Chen, Yang Liu, Li Tong, Jiamian Chu, Kecen Xiao, Zhiyu Zhou, Wenbo Dong, Xingwu Chu   +8 more
doaj   +1 more source

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine

, 2020
INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan, Beyzavi, M. Hassan, De Lombaerde, Stef, De Vos, Filip, Descamps, Benedicte, Donche, Sam, Goethals, Ingeborg, Hu, Jiyun, Lambe, Patricia, Pauwelyn, Glenn, Piron, Sarah, Vanhove, Christian, Verhoeven, Jeroen   +12 more
core   +1 more source

Dual-functionalization device for therapy through dopamine release and monitoring [PDF]

, 2018
"This is the pre-peer reviewed version of the following article: G. Fabregat, A. Giménez, A. Díaz, J. Puiggalí, C. Alemán, Macromol. Biosci. 2018, 18, 1800014 , which has been published in final form at https://doi.org/10.1002/mabi.201800014 .
Alemán Llansó, Carlos, Díaz Andrade, Angélica María, Fabregat Jové, Georgina, Giménez, Alessia, Puiggalí Bellalta, Jordi   +4 more
core   +2 more sources

Electrospun conducting polymers: recent trends and the transition towards a sustainable future

Polymer International, EarlyView.
This review discusses the electrospinning of conducting polymers, detailing procedures, fibrous morphologies, improved properties, applications in electronics, and challenges, while outlining future directions for nanofibre‐based devices in various fields.
Xenofon Karagiorgis, Sofia Sandhu, Peter J. Skabara, Ravinder Dahiya   +3 more
wiley   +1 more source

Effects of poly-γ-glutamic acid (γ-PGA) on plant growth and its distribution in a controlled plant-soil system

Scientific Reports, 2017
To demonstrate the responses of plant (Pakchoi) and soil to poly-γ-glutamic acid (γ-PGA) is essential to better understand the pathways of the promotional effect of γ-PGA on plant growth. In this study, the effects of γ-PGA on soil nutrient availability,
Lei Zhang, Xueming Yang, Decai Gao, Lingli Wang, Jie Li, Zhanbo Wei, Yuanliang Shi   +6 more
doaj   +1 more source

Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy. [PDF]

, 2016
Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle ...

core   +2 more sources

Tuning adsorption and morphology in poly(glutamic acid) via controlled acidic partial deprotection

Polymer International, EarlyView.
Partial deprotection of poly(glutamic acid) generates morphologies and assemblies that match fully deprotected polypeptides in small‐molecule adsorption, extending to block copolypeptides with pH‐dependent effects. Abstract Synthetic polypeptides prepared from N‐carboxyanhydride (NCA) monomers are important platforms for environmental and medical ...
Hunter Wood, Stella Trickett, Joseph Dosch, Farin Weinger, Dan Flaherty, Stefanie Sydlik   +5 more
wiley   +1 more source