Results 121 to 130 of about 16,681,036 (304)

CONTROLLED-RELEASE OF PROTEINS FROM POLY(L-LACTIC ACID) COATED POLYISOBUTYLCYANOACRYLATE MICROCAPSULES

, 1994
Poly (L-lactic acid) -coated polyisobutylcyanoacrylate microcapsules containing protein molecules were prepared by a single-step procedure based on either a double-emulsion-solvent evaporation method or a spray-drying method.
TAE GWAN PARK
core   +1 more source

The Potential of Self‐Maintainable Living Materials

Advanced Science, EarlyView.
Self‐maintainable living materials are presented as the next generation of bioadaptive systems, integrating continuous sensing, decision‐making, response, self‐repair, and adaptation in a closed‐loop framework. This review highlights the design principles and emerging technologies that enable autonomous, long‐term functionality for future regenerative ...
Mohammadsadegh Nadimifar, Tatiane Eufrásio‐da‐Silva, Lidia Maeso, Gorka Orive, Alireza Dolatshahi‐Pirouz   +4 more
wiley   +1 more source

Pilot Cross-Platform Bench Characterization of Injectable Biostimulator Products Using a Predefined Descriptive Workflow

Biomedicines
Background/Objectives: This descriptive pilot documented preparation-related, microscopic, and aqueous-exposure appearances of nine injectable biostimulator products spanning poly-L-lactic acid (PLLA), poly-D,L-lactic acid (PDLLA), polycaprolactone (PCL),
Wojciech Gruszczyński, Monika Filipowska, Paweł Kubik   +2 more
doaj   +1 more source

Biological Response of Intramedullary Bone to Poly-L-Lactic Acid

, 1991
Bioabsorbable synthetic polymers have been studied for their possible application in absorbable internal fracture fixation devices. The current study examines the biological response of intramedullary bone to PLLA (poly-L-lactic acid). PLLA degrades at a
J. Traub, J. L. Ricci, J. Suganuma, H. Alexander   +3 more
core   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Preparation of microcellular poly(lactic acid) composites foams with improved flame retardancy

, 2017
In this study, flame-retardant poly(lactic acid) foams with satisfactory cell structures were prepared by microcellular foaming technology using phosphorus-containing flame retardant and graphene as the charring agent.
Wang, Jingjing, Zhai, Wentao, Zhao, Dan, Wang, Kun   +3 more
core  

Thermal properties of a new class of block copolymers based on segments of poly(D,L-lactic-glycolic acid) and poly(e-caprolactone)

, 2000
The results of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and dynamic-mechanical thermal analysis (DMTA) investigations performed on a new class of multi-block copolymers based on poly(d,l-lactic-glycolic acid) (PLGA) and ...
S. D'ANTONE, BIGNOTTI, Fabio, Sartore L., Di Landro L., SARTORE, Luciana, F. Bignotti, M. Penco, Penco M., L. DI LANDRO, L. Sartore, D'Antone S., PENCO, Maurizio, Bignotti F., D'ANTONE, SALVATORE, DI LANDRO, LUCA ANGELO, Luca Di Landro, Luciana Sartore, Maurizio Penco, Salvatore D’Antone, Fabio Bignotti   +19 more
core   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Synthesis, stereocomplex crystallization and homo-crystallization of enantiomeric poly(lactic acid-co-alanine)s with ester and amide linkages

, 2018
α-Hydroxy acid and α-amino acid-derived poly(l-lactic acid-co-l-alanine)s and poly(d-lactic acid-co-d-alanine)s with different alanine unit contents were synthesized and their stereocomplex crystallization and homo-crystallization were investigated.
Hideto Tsuji, Yuki Arakawa, Noriaki Masaki, Akinori Kuzuya, Yuichi Ohya, Shotaro Sato   +5 more
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source