Results 81 to 90 of about 116,530,352 (255)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Morphology of poly ethylene oxide dissolved in a room temperature ionic liquid a small angle neutron scattering study

, 2006
Solutions of deuterated poly(ethylene oxide) (d-PEO) in 1-butyl-3-methyl imidazolium tetrafluoroborate ([bmim][BF4]), a prototype room-temperature ionic liquid (RTIL), have been studied at room temperature over a range of polymer concentrations, using ...
KOHLBRECHER J., Triolo, A., Keiderling, U., Kohlbrecher, J., TRIOLO A, Russina, O., KEIDERLING U, RUSSINA, OLGA   +7 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Comparing the emission spectra of U and Th hollow cathode lamps and a new U line list

, 2018
Context. Thorium hollow cathode lamps (HCLs) are used as frequency calibrators for many high resolution astronomical spectrographs, some of which aim for Doppler precision at the 1 m s−1 level. Aims.
E. W. Guenter, F. F. Bauer, Seemann, U., Guenter, E. W., U. Wolter, Bauer, F. F., A. Reiners, Huke, P., U. Seemann, Sarmiento, L. F., Reiners, A., L. F. Sarmiento, Wolter, U., P. Huke   +13 more
core   +1 more source

Mikrokapsle poly(methylmethakrylát – kopolymer) / kyseliny n-hexadekanové pro tepelný komfort textilií [PDF]

ACC Journal, 2014
Tepelný komfort získaný pomocí mikrokapsulovaných materiálů se změnou fází (MPCMs) u inovačních textilních výrobků je široce zkoumán pro svou vysokou přidanou hodnotou, a procesy spojené s aplikací mikrokapslí na textilie se rapidně zrychlují ve snaze ...
Ruhan Altun Anayurt, Alev Arslan, Derya Kahraman Döğüşcü, Cemil Alkan, Sennur Alay Aksoy   +4 more
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Binding of $TMPyP^{3+}$ porphyrin to poly(A)-poly(U) polynucleotide: a spectroscopic study [PDF]

The porphyrins are macrocyclic compounds widely used as photosensitizers in anticancer photodynamic therapy. The binding of a tricationic meso-tris(N-methylpyridinium)-porphyrin, $TMPyP^{3+}$, to poly(A)-poly(U) polynucleotide has been studied in neutral
Dubey, Igor Ya., Voloshin, Igor M., Ryazanova, Olga A., Karachevtsev, Victor A., Dubey, Larysa V.   +4 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source