Results 71 to 80 of about 547,441 (316)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interactions, structure and properties in poly(lactic acid)/thermoplastic polymer blends

, 2014
Blends were prepared from poly(lactic acid) (PLA) and three thermoplastics, polystyrene (PS), polycarbonate (PC) and poly(methyl methacrylate) (PMMA). Rheological and mechanical properties, structure and component interactions were determined by various ...
B. Pukanszky, Renner, Károly, B. Imre, Pukánszky, Béla, K. Renner, Imre, Balázs   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A versatile characterization of poly(N-isopropylacrylamideco- N,N'-methylene-bis-acrylamide) hydrogels for composition, mechanical strength, and rheology

, 2013
Poly(N-isopropylacrylamide-co-N,N"-methylene-bisacrylamide) (P(NIPAAm-co-MBA)) hydrogels were prepared in water using redox initiator. The copolymer composition at high conversion (> 95%) was determined indirectly by HPLC (high performance liquid ...
Sulyok, Zsolt, Fekete, Jenő, Domján, Attila, A. Meszaros, A. Szilagyi, Chetty, A., Zs. Sulyok, V. Vargha, Szilágyi, András, Mészáros, Á., Kovács, János, J. Kovacs, A. Chetty, Vargha, Viktória, J. Fekete, A. Domjan   +15 more
core   +1 more source

Additive and transcript-specific effects of KPAP1 and TbRND activities on 3' non-encoded tail characteristics and mRNA stability in Trypanosoma brucei. [PDF]

PLoS ONE, 2012
Short, non-encoded oligo(A), oligo(U), or A/U tails can impact mRNA stability in kinetoplastid mitochondria. However, a comprehensive picture of the relative effects of these modifications in RNA stability is lacking.
Sara L Zimmer, Sarah M McEvoy, Sarita Menon, Laurie K Read   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Associations hélicoïdales de poly A et poly U en milieu acide. Transitions irréversibles

, 2017
Dans cet article, nous étudions la stabilité thermique de poly (A + U) et poly (A + 2U) en milieu acide. Dans ces conditions, poly A s’associe avec lui-même pour former une double hélice, poly (A2).
Jean Massoulié
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mikrokapsle poly(methylmethakrylát – kopolymer) / kyseliny n-hexadekanové pro tepelný komfort textilií [PDF]

ACC Journal, 2014
Tepelný komfort získaný pomocí mikrokapsulovaných materiálů se změnou fází (MPCMs) u inovačních textilních výrobků je široce zkoumán pro svou vysokou přidanou hodnotou, a procesy spojené s aplikací mikrokapslí na textilie se rapidně zrychlují ve snaze ...
Ruhan Altun Anayurt, Alev Arslan, Derya Kahraman Döğüşcü, Cemil Alkan, Sennur Alay Aksoy   +4 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source