Results 91 to 100 of about 116,530,352 (255)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Characterization of the steady-state population of the poly(adenylic acid) sequences in a rat hepatoma and in normal liver.

, 1982
In steady state conditions, the content and size distribution of the poly(A) segments obtained by nuclease digestion of the total RNA from normal liver and a fast growing hepatoma (H 3924 A) are different.
Sacchi A, Mattei E, Delpino A, Ferrini U
core  

Linear and nonlinear rheological behavior and crystallization of semicrystalline poly(styrene)–poly(L-lactide) block copolymers

, 2013
The rheological behavior of a poly(styrene)-poly(L-lactide) (PS-PLLA) block copolymer was investigated in the viscoelastic linear and nonlinear regime.
Malek, A., Dingenouts, N., Barner, L., Wilhelm, M., Fehrenbacher, U., Beskers, T. F.   +5 more
core   +1 more source

Enhanced toughness of PLLA/PCL blends using poly(d-lactide)-poly(ε-caprolactone)-poly(d-lactide) as compatibilizer

, 2020
Poly(l-lactide) (PLLA)/poly(ε-caprolactone) (PCL) blends traditionally show low ductility because of the immiscibility between PLLA and PCL. In this study, this ductility challenge was addressed by modifying the compatibility between PLLA and PCL using ...
Yang, Yihu, Yu, Bin, Song, Pingan, Xiao, Xianglian, Chevali, Venkata S., Wang, Hao   +5 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Associations hélicoïdales de poly A et poly U en milieu acide. Transitions irréversibles

, 2017
Dans cet article, nous étudions la stabilité thermique de poly (A + U) et poly (A + 2U) en milieu acide. Dans ces conditions, poly A s’associe avec lui-même pour former une double hélice, poly (A2).
Jean Massoulié
core   +1 more source

Poly-L-lactic acid for HIV-1 facial lipoatrophy: 48-week follow-up [PDF]

, 2009
Poly-L-lactic acid for HIV-1 facial lipoatrophy: 48-week follow ...
Gary Rogers (13091598), D Carey (13283520), DA Cooper (12507691), A Carr (7766963), J Watson (7788164), S Emery (7719341), J Chuah (13312725), K Petoumenos (9898619), D Baker (7724024)   +8 more
core   +2 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Calorimetric measurement of transition enthalpies in the polynucleotidesystem poly A-poly U [PDF]

, 1967
Neumann E, Ackermann T. Calorimetric measurement of transition enthalpies in the polynucleotidesystem poly A-poly U. Journal of Physical Chemistry.
Ackermann, Theodor, Neumann, Eberhard
core   +1 more source