Results 111 to 120 of about 25,360,752 (379)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Hyperglycemia-Induced Involuntary Movements: 2 Case Reports and a Review of the Literature

AACE Clinical Case Reports, 2015
: Objective: Autonomic and peripheral neurologic manifestations of hyperglycemia are commonly seen in clinical practice; acute hyperglycemia-induced involuntary movements (HIIM) are rarer and less well known.
Alejandra Borensztein, MD, Ruth H. Walker, MB, ChB, PhD, Robert Schell, MD, Helena A. Guber, MD   +3 more
doaj  

ANALYSIS OF HEALTH SERVICES MAXIMUM SUPPLY IN HOSPITAL SURABAYA

JPH RECODE (Journal of Public Health Research and Community Health Development), 2019
The importance of a health service  in calculating the maximum supply is to ensure efficiency and effectiveness. To achieve efficiency and effectiveness it is important to pay attention to the combination of Human Resources and other resources ...
Novia Dewi Putri Ayuningtyas
doaj   +1 more source

N6-methyladenosine in poly(A) tails stabilize VSG transcripts

Nature, 2022
Idálio J. Viegas, J. P. de Macedo, Lúcia Serra, Mariana De Niz, A. Temporão, Sara Silva Pereira, Aashiq H. Mirza, Ed Bergstrom, J. Rodrigues, Francisco Aresta-Branco, S. Jaffrey, L. Figueiredo   +11 more
semanticscholar   +1 more source

Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A) [PDF]

, 1977
A template-dependent RNA polymerase has been isolated from poliovirus-infected cells by assaying for the ability of the enzyme to copy poly(A) complexed to an oligo(U) primer.
Baltimore, David, Flanegan, James B.
core  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Ending the message: poly(A) signals then and now.

Genes & Development, 2011
Polyadenylation [poly(A)] signals (PAS) are a defining feature of eukaryotic protein-coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and subsequently shown to require flanking, auxiliary elements for both 3'-end cleavage ...
N. Proudfoot
semanticscholar   +1 more source

Detection of DNA and Poly-L-Lysine using CVD Graphene-channel FET Biosensors

, 2015
A graphene channel field-effect biosensor is demonstrated for detecting the binding of double-stranded DNA and poly-l-lysine. Sensors consist of CVD graphene transferred using a clean, etchant-free transfer method.
Abhilash, T. S., Craighead, Harold G, De Alba, Roberto, Kakatkar, Aniket, Parpia, Jeevak M   +4 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A convenient and adjustable surface-modified complex containing poly-L-glutamic acid conjugates as a vector for gene delivery

International Journal of Nanomedicine, 2008
Ye Sun1, Yuzhao Tang1, Maoquan Chu2, Shuxian Song1, Yanfei Xin31School of Life Science and Technology, Shanghai Jiaotong University, Shanghai, China; 2Institute of Life Science and Technology, Tongji University, Shanghai, China; 3School of Pharmacy ...
Ye Sun, Yuzhao Tang, Maoquan Chu, Shuxian Song, Yanfei Xin   +4 more
doaj