Results 131 to 140 of about 27,595,942 (347)
Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein
RNA: A publication of the RNA Society, 2013 The RNA recognition motif (RRM) is the most common eukaryotic RNA-binding domain, with differences in its amino acid sequence affecting binding specificity and affinity.
D. Melamed +4 more
semanticscholar +1 more source
TGA/FTIR: An Extremely Useful Technique for Studying Polymer Degradation [PDF]
, 1999 Thermogravimetric analysis coupled to Fourier transform infrared spectroscopy, TGA/FTIR, has been used to probe the degradation of several polymeric systems.
Wilkie, Charles A.
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.
Genes & Development, 1991 The cap structure and the poly(A) tail are important regulatory determinants in establishing the translational efficiency of a messenger RNA. Although the mechanism by which either determinant functions remains poorly characterized, the interaction ...
D. Gallie
semanticscholar +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
HeliyonSmall molecules as ligands target multifunctional ribonucleic acids (RNA) for therapeutic engagement. This study explores how the anticancer DNA intercalator harmine interacts various motifs of RNAs, including the single-stranded A-form poly (rA), the ...
Paromita Sarkar +7 more
doaj +1 more source
Polyimides prepared from 3,5-diamino benzo trifluoride [PDF]
, 1993 High performance, thermooxidatively stable polyimides are prepared by reacting aromatic diamines with pendant trifluoromethyl groups and dianhydrides in an amide solvent to form a poly(amic acid), followed by cyclizing the poly(amic acid) to form the ...
Gerber, Margaret K. +3 more
core +1 more source
Poly-Poisson Sigma models and their relational poly-symplectic groupoids
, 2017 The main idea of this note is to describe the integration procedure for poly-Poisson structures, that is, to find a poly-symplectic groupoid integrating a poly-Poisson structure, in terms of topological field theories, namely via the path-space ...
Alba, Nicolás Martínez +1 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal of Manufacturing and Materials ProcessingThe problems created by conventional polymers after their end use have driven research into new biodegradable polymeric materials. PLA is a compostable polymer obtained from renewable sources, but its main drawbacks are its fragility and slow ...
Aitor Arbelaiz +2 more
doaj +1 more source