Results 111 to 120 of about 115,568,697 (304)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Poly(A)+ selection limits detection of long and alternatively spliced transcripts compared with rRNA depletion in RNA-Sequencing

BMC Genomics
The eukaryotic transcriptome diversity arises largely from alternative splicing. One of the widely used high-throughput methods to study this diversity is RNA sequencing.
Swethaa Natraj Gayathri, Victoria Lillback, Bjarne Udd, Peter Hackman, Marco Savarese, Ali Oghabian   +5 more
doaj   +1 more source

Construction of Sensitive Amperometric Immunosensor Based on Poly(amidoamine) Dendrimer and One-step Ionic-liquid-assisted Graphene/Chitosan Platform for Benzo[a]pyrene Detection

International Journal of Electrochemical Science, 2012
A novel electrochemical immunosensor was proposed using a poly(amidoamine) dendrimer (PAMAM) modified ionic-liquid-assisted graphene sheets-doped chitosan (GS-CS) hybrid matrix as platform, which were characterized by cyclic voltammograms and scanning ...
Mouhong Lin, Yingju Liu, Zhuohong Yang, Yibin Huang, Zihong Sun, Yuan He, Chunlin Ni   +6 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation [PDF]

, 2014
Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each ...
Wilson, Neil R., Dyson, M.A., Schiller, Tara L, Dove, Andrew P., Schiller, T.L., Schiller, Tara, Dyson, M Adam, Sanchez, A.M., Sun, Liang, O'Reilly, R.K., Wilson, Neil R, Pitto-Barry, Anaïs, Schiller, Tara L., Kirby, Nigel, Sloan, Jeremy, Dyson, Mark Adam, Sun, L., O'Reilly, Rachel K; id_orcid, O'Reilly, Rachel K, Sloan, J., O’Reilly, Rachel K., Dove, Andrew P, Sanchez, Ana M., Kirby, N., Wilson, N.R., Dove, A.P., Sanchez, Ana M   +26 more
core   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Synthesis and post-polymerisation functionalisation of aliphatic poly(carbonate)s [PDF]

This work describes the controlled organocatalytic ring-opening polymerisation (ROP) of cyclic carbonates with pendant groups for the preparation of functional aliphatic poly(carbonate)s and poly(estercarbonate) s. Their subsequent post-polymerisation
Tempelaar, Sarah
core  

A Preliminary Study on the Usage of Tik Tok as Shopping Platform: A Survey in Kolej Poly-Tech MARA Ipoh [PDF]

The rapid digital transformation brought about by the COVID-19 pandemic has reshaped the way businesses engage with consumers. This study explores the usage of TikTok Shop as a shopping platform among Diploma in Digital Marketing students at Kolej Poly ...
Anuar, Nurul Husna, Rahim, Norafni @ Farlina   +1 more
core   +1 more source

Insights on the comparative affinity of ribonucleic acids with plant-based beta carboline alkaloid, harmine: Spectroscopic, calorimetric and computational evaluation

Heliyon
Small molecules as ligands target multifunctional ribonucleic acids (RNA) for therapeutic engagement. This study explores how the anticancer DNA intercalator harmine interacts various motifs of RNAs, including the single-stranded A-form poly (rA), the ...
Paromita Sarkar, Priyanka Gopi, Prateek Pandya, Samaresh Paria, Maidul Hossain, Manzer H. Siddiqui, Saud Alamri, Kakali Bhadra   +7 more
doaj   +1 more source

Low‐Temperature Imidization of Polyimides (PI) for Scalable Manufacturing of Flexible Wearable Electronics

Advanced Engineering Materials, EarlyView.
Low‐temperature imidization of PEG‐modified polyimide enables fully screen‐printed, roll‐to‐roll fabrication of flexible electrodes on PET substrates, delivering robust mechanical durability and reliable ECG/EMG signal performance for wearable electronics.
Akib Abdullah Khan, Jong‐Hoon Kim
wiley   +1 more source