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N6-methyladenosine in poly(A) tails stabilize VSG transcripts
Nature, 2022RNA modifications are important regulators of gene expression1. In Trypanosoma brucei, transcription is polycistronic and thus most regulation happens post-transcriptionally2. N6-methyladenosine (m6A) has been detected in this parasite, but its function remains unknown3.
Viegas, Idálio +11 more
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Poly(A) tails: longer is not always better
Nature Structural & Molecular Biology, 2017Deadenylation of mRNAs is generally associated with translational inhibition and mRNA decay. A study now reports that, unexpectedly, highly expressed genes tend to have shorter poly(A) tails and suggests that poly(A) tails can be 'pruned', generating a 30-nucleotide-biased phased distribution, likely due to protection by poly(A)-binding proteins.
Luciana A, Castellano, Ariel A, Bazzini
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Differential Poly(A) Tail Length Analysis Using Nanopore Sequencing
2023The poly(A) tail is a sequence of several adenosine nucleotides added to the 3' end of RNA molecules transcribed by polymerase II. The dynamics of poly(A) tail length play a significant role in regulating post-transcriptional gene expression by regulating the stability, translation, and decay of messenger RNAs.
Showkat A, Dar +3 more
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Beyond simple tails: poly(A) tail-mediated RNA epigenetic regulation
Trends in Biochemical SciencesThe poly(A) tail is an essential structural component of mRNA required for the latter's stability and translation. Recent technologies have enabled transcriptome-wide profiling of the length and composition of poly(A) tails, shedding light on their overlooked regulatory capacities.
Jingwen Liu, Falong Lu
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Mathematical Modeling of mRNA Poly(A) Tail Shortening Process
2023A sequence of deadenylation events, or the shortening of the poly(A) tail, is a highly regulated process during the life cycle of mRNAs. Advances in biochemistry have enabled the study of deadenylation events at single-nucleotide resolution. Here we describe mathematical models and their applications to estimate the kinetics of a single deadenylation ...
Benedict, Fabia +3 more
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Measuring the Length of Poly(A) Tails
Cold Spring Harbor Protocols, 2015Adenylation status has an important role in the regulation of mRNA metabolism: mRNAs are deadenylated before degradation, microRNAs (miRNAs) can cause deadenylation, and the poly(A) length of certain mRNAs is regulated during development. This protocol describes methods that can be used to measure the poly(A) tail length of specific mRNAs.
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Poly(A)-Tailed Universal Reverse Transcription
2009Zheng’ laboratory from the Beijing Institute of Radiation Medicine (Beijing, People’s Republic of China) and Yan’s laboratory from the Department of Physiology and Cell Biology, the University of Nevada School of Medicine (Reno, NV, USA) independently established the Poly(A)-Tailed Universal Reverse Transcription technique, a simple method to detect ...
Zhiguo Wang, Baofeng Yang
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Poly(A) tail synthesis and regulation: recent structural insights
Current Opinion in Structural Biology, 2002Polyadenylation at the 3' ends of mRNAs is critical to the translation and stability of the messages. Recently determined structures of poly(A) polymerase, U1A and domains of the poly(A)-binding protein provide a framework for understanding the synthesis and regulation of the poly(A) tail.
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m6A-modified RNAs possess distinct poly(A) tails
Journal of Genetics and Genomics, 2023Shuang Wu +5 more
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Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
Nature Reviews Molecular Cell Biology, 2021Lori Anne Passmore, Jeff Coller
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