Results 81 to 90 of about 13,318 (225)

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Regulation of poly(ADP-ribose) polymerase mRNA levels during compensatory and mitogen-induced growth of rat liver.

, 1990
Poly(ADP-ribose) polymerase mRNA levels were studied in hepatic regeneration following partial hepatectomy, and in hyperplasia induced by the mitogen lead nitrate.
De Prati A. C, Menegazzi M, Miwa M, Suzuki H., COLUMBANO, AMEDEO, Uchida K, LEDDA, GIOVANNA MARIA   +6 more
core   +2 more sources

The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation.

PLoS Biology, 2008
ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown.
Anna Sala, Gaspare La Rocca, Giosalba Burgio, Elena Kotova, Dario Di Gesù, Marianna Collesano, Antonia M R Ingrassia, Alexei V Tulin, Davide F V Corona   +8 more
doaj   +1 more source

Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors

, 2016
Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines.
Jianke Li (219587), David R. Newell (129326), Brian W. Eastman (3016296), A. Hilary Calvert (2219308), Stephen E. Webber (2471281), Roger J. Griffin (129311), Anne Ekker (3016311), Xiao-Hong Yu (2134060), Donald J. Skalitzky (3016314), Bernard T. Golding (129309), Zdenek Hostomsky (3016299), Nicola J. Curtin (351064), Joseph T. Marakovits (3016305), Robert Almassy (3016302), Karen A. Maegley (3016308)   +14 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1 [PDF]

, 2008
Shelterin/telosome is a multi-protein complex at mammalian telomeres, anchored to the double-stranded region by the telomeric-repeat binding factors-1 and -2.
Cohausz, Odile, Boukamp, P, S. Beneke, Cohausz, O, Bürkle, A, Bürkle, Alexander, F. Althaus, A. Bürkle, P. Boukamp, Beneke, Sascha, Malanga, M, O. Cohausz, MALANGA, MARIA, Boukamp, Petra, Beneke, S, Althaus, Felix   +15 more
core   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Mitotic functions of poly(ADP-ribose) polymerases

Biochemical Pharmacology, 2019
Mitosis ensures accurate segregation of duplicated DNA through tight regulation of chromosome condensation, bipolar spindle assembly, chromosome alignment in the metaphase plate, chromosome segregation and cytokinesis. Poly(ADP-ribose) polymerases (PARPs), in particular PARP1, PARP2, PARP3, PARP5a (TNKS1), as well as poly(ADP-ribose) glycohydrolase ...
openaire   +3 more sources

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation

Nature Communications, 2019
The study of NAD+ dependent ADP-ribosylation can be challenging. Here the authors report on the development of NAD+ analogues, using chemo-enzymatic methods, which can be used as probes to label the substrate proteins of poly-ADP-ribose polymerase.
Xiao-Nan Zhang, Qinqin Cheng, Jingwen Chen, Albert T. Lam, Yanran Lu, Zhefu Dai, Hua Pei, Nikolai M. Evdokimov, Stan G. Louie, Yong Zhang   +9 more
doaj   +1 more source