Results 131 to 140 of about 72,887 (326)

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis [PDF]

, 2018
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease. Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly leading to death within ~ 2–5 years of symptomatic onset. There is no cure, and
A Chiarugi, A Chiarugi, A Sonnenblick, AA Fatokun, AC Elden, AE Renton, AK Leung, B Luscher, B Nefussy, BA Gibson, C Benkler, C Cosi, C Culmsee, C Hewitt, C Vance, CR Calabrese, D Petrov, DR Rosen, DR Thal, E Bentmann, E Kiskinis, E Turunc Bayrakdar, EM Park, EV Hobson, F Geser, F Moroni, G Kim, GE Abdelkarim, GM Shah, Group AS, Group AS, H Braak, H Braak, H Farmer, H Kawamitsu, H Sawada, H Yokoyama, HE Bryant, HJ Kim, HT Chung, IG McKeith, IR Mackenzie, J Brettschneider, J Mojsilovic-Petrovic, J Mojsilovic-Petrovic, J Rosenfeld, J Sreedharan, J Zhang, JC Morris, JD Rothstein, JD Rothstein, JD Rothstein, JP Taylor, JS Bae, K Takahashi, K Uryu, K Zhang, KW Caldecott, L Lehtio, L Liu-Yesucevitz, L Mariotti, L McGurk, L Van Den Bosch, LA Becker, LP Rowland, M Altmeyer, M Citarelli, M DeJesus-Hernandez, M Endres, M Endres, M Hasegawa, M Isabelle, M Naumann, M Neumann, M Neumann, M Neumann, MA Farg, MJ Finelli, MO Hottiger, NA Berger, NL Kedersha, O Hardiman, O Spreux-Varoquaux, OA Andreassen, P Anderson, PJ Shaw, PL Oliver, R Gupte, R Krishnakumar, RH Tan, S Hanai, S Martire, S Martire, S Saxena, SA Andrabi, SB Gibson, SC Ling, SH Kaufmann, SH Kim, SH Kim, SH Koh, SL Rulten, SS Mirra, T Haikarainen, TJ Kwiatkowski Jr, TM Kauppinen, V Schreiber, VL Dawson, X Luo, Y Wang, YH Chung, YR Li, ZY Abd Elmageed   +112 more
core   +2 more sources

Treatment Response and Outcomes of Prostate Cancer Patients Carrying the Germline MMS22L F722fs Mutation

The Prostate, EarlyView.
ABSTRACT Background Methyl Methanesulfonate‐Sensitivity Protein 22‐Like (MMS22L) plays a key role in homology‐directed DNA repair, and experimental models have shown that its loss confers sensitivity to Poly (ADP‐ribose) polymerase inhibitors (PARPi).
Mayuko Kanayama, Violet A. Daniels, Marta Gielzak, Alex Brame, Misop Han, Li Jia, Jianfeng Xu, Tamara L. Lotan, Mario A. Eisenberger, Catherine H. Marshall, Patrick C. Walsh, William B. Isaacs, Jun Luo   +12 more
wiley   +1 more source

Genomic and Clinical Impact of Smoking on Therapeutic Outcomes in Prostate Cancer: A Public Databases Analysis

The Prostate, EarlyView.
ABSTRACT Background In prostate cancer (PCa), smoking history is associated with more aggressive clinicopathological features, reduced efficacy of androgen deprivation therapy, and poorer overall survival (OS). However, its impact on survival outcomes in patients receiving taxane chemotherapy, poly ADP‐ribose polymerase inhibitor (PARPi), or immune ...
Tomoya Hatayama, Yohei Sekino, Go Kobayashi, Kazuma Yukihiro, Yoshinori Nakano, Shinsaku Tasaka, Naofumi Nomura, Yuki Kohada, Kenshiro Takemoto, Miki Naito, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata   +16 more
wiley   +1 more source

Real-world Outcomes Associated With Poly(ADP-ribose) Polymerase Inhibitor Monotherapy Maintenance in Patients With Primary Advanced Ovarian Cancer

, 2023
John K. Chan, Jinan Liu, Jinlin Song, Cheryl Xiang, Eric Q. Wu, Linda Kalilani, Jean Hurteau, Premal H. Thaker   +7 more
openalex   +1 more source

Poly (ADP Ribose) Polymerase Inhibitors for Cancer [PDF]

The Journal of Molecular Diagnostics, 2020
Lynette M. Sholl, Diana Mandelker, Tracy Stockley   +2 more
openaire   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells [PDF]

, 2015
Ahrum Min, Seock‐Ah Im, Debora Keunyoung Kim, Sang-Hyun Song, Hee Jun Kim, Kyung-Hun Lee, Tae‐Yong Kim, Sae‐Won Han, Do‐Youn Oh, Tae‐You Kim, Mark J. O’Connor, Yung‐Jue Bang   +11 more
openalex   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Poly(ADP-Ribose) Polymerase (PARP) Inhibitors for Cancer Therapy: Advances, Challenges, and Future Directions

Biomolecules
Poly(ADP-ribose) polymerases (PARPs) are crucial nuclear proteins that play important roles in various cellular processes, including DNA repair, gene transcription, and cell death.
Denys Bondar, Yevgen Karpichev
doaj   +1 more source