Results 71 to 80 of about 285 (107)

Cellular gene delivery via poly(hexamethylene biguanide)/pDNA self-assembled nanoparticles [PDF]

open access: yesEuropean Journal of Pharmaceutics and Biopharmaceutics, 2021
Cellular gene delivery via polycations has wide implications for the potential of gene therapy, but it has remained a challenge due to the plethora of pre- and post-uptake barriers that must be overcome to reach desired efficiency. Herein we report poly(hexamethylene biguanide) (PHMB) as a nano-vector for intracellular delivery of plasmid DNA (pDNA ...
Wenhui Song   +2 more
exaly   +4 more sources
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Antibacterial efficacy of chitosan- and poly(hexamethylene biguanide)-immobilized nanofiber membrane

International Journal of Biological Macromolecules, 2020
In this study, polyacrylonitrile (PAN) nanofiber membrane was prepared by an electrospinning technique. After alkaline hydrolysis, the ion-exchange nanofiber membrane (P-COOH) was grafted with chitosan molecules to form a chitosan-modified nanofiber membrane (P-COOH-CS). Poly(hexamethylene biguanide) (PHMB) was then covalently immobilized on P-COOH and
Chen-Yaw Chiu   +2 more
exaly   +3 more sources

Antibacterial efficacy of poly(hexamethylene biguanide) immobilized on chitosan/dye-modified nanofiber membranes

International Journal of Biological Macromolecules, 2021
This study aimed to develop a novel electrospun polyacrylonitrile (PAN) nanofiber membrane with the enhanced antibacterial property. The PAN nanofiber membrane was first subjected to alkaline hydrolysis treatment, and the treated membrane was subsequently grafted with chitosan (CS) to obtain a CS-modified nanofiber membrane (P-COOH-CS).
Cher Pin Song   +2 more
exaly   +3 more sources

Covalently construction of poly(hexamethylene biguanide) as high-efficiency antibacterial coating for silicone rubber

Chemical Engineering Journal, 2021
Abstract Biofilm formation on biomedical devices & implants and the resulting bacterial induced infections are remaining severe clinic issues. Here, a facile layer-by-layer strategy to covalently construct poly(hexamethylene biguanide) (PHMB) as the high-efficiency bactericidal coating on silicone rubber (SR) has been developed.
Peiming Liu, Shen Jian, Pingsheng Liu
exaly   +2 more sources

Poly(hexamethylene biguanide) (PHMB) as high-efficiency antibacterial coating for titanium substrates

Journal of Hazardous Materials, 2021
Bacterial associated infection is a remaining urgent challenge in clinic application of metallic implants and devices. Here, we developed a new strategy to combat the bacterial associated infection of titanium alloy (TC4). Novel phosphonate/active ester block polymers (pDEMMP-b-pNHSMA) with identical phosphonate segments (DP = 29) as the metal ...
Jiangmei, Peng   +8 more
openaire   +2 more sources

Antimicrobial electrospun membranes of chitosan/poly(ethylene oxide) incorporating poly(hexamethylene biguanide) hydrochloride

Carbohydrate Polymers, 2013
Here, antimicrobial nanofibrous membranes were produced by electrospinning of chitosan/poly(ethylene oxide) (PEO) solution in the presence of poly(hexamethylene biguanide) hydrochloride (PHMB). The influence of PHMB on the electrospinnability and antimicrobial properties of chitosan/PEO nanofibers were studied.
M Montazer
exaly   +3 more sources

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