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Antibacterial efficacy of chitosan- and poly(hexamethylene biguanide)-immobilized nanofiber membrane
International Journal of Biological Macromolecules, 2020In this study, polyacrylonitrile (PAN) nanofiber membrane was prepared by an electrospinning technique. After alkaline hydrolysis, the ion-exchange nanofiber membrane (P-COOH) was grafted with chitosan molecules to form a chitosan-modified nanofiber membrane (P-COOH-CS). Poly(hexamethylene biguanide) (PHMB) was then covalently immobilized on P-COOH and
I-Son Ng, Chien Wei Ooi, Bing-Lan Liu
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This study aimed to develop a novel electrospun polyacrylonitrile (PAN) nanofiber membrane with the enhanced antibacterial property. The PAN nanofiber membrane was first subjected to alkaline hydrolysis treatment, and the treated membrane was subsequently grafted with chitosan (CS) to obtain a CS-modified nanofiber membrane (P-COOH-CS).
Chien Wei Ooi +2 more
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Abstract Biofilm formation on biomedical devices & implants and the resulting bacterial induced infections are remaining severe clinic issues. Here, a facile layer-by-layer strategy to covalently construct poly(hexamethylene biguanide) (PHMB) as the high-efficiency bactericidal coating on silicone rubber (SR) has been developed.
Wan Peng, Jian Shen
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Here, antimicrobial nanofibrous membranes were produced by electrospinning of chitosan/poly(ethylene oxide) (PEO) solution in the presence of poly(hexamethylene biguanide) hydrochloride (PHMB). The influence of PHMB on the electrospinnability and antimicrobial properties of chitosan/PEO nanofibers were studied.
M Montazer
exaly +3 more sources

