Results 161 to 170 of about 509,057 (336)

Virome and Experimental Analysis Reveal Tryptophan‐Like Dissolved Organic Matter Contributes to the Persistence of Plant Viruses in River Water

open access: yesAdvanced Science, EarlyView.
Tryptophan‐like dissolved organic matter (Try‐like DOM), a key component of organic matter in river ecosystems, demonstrates significant protective effects against plant viruses. The protective mechanism operates via a “swimming firewall” mode, whereby free Try‐like DOM attenuates ultraviolet (UV) radiation and scavenges reactive oxygen species ...
Yujie Wang   +7 more
wiley   +1 more source

Protein stabilization explains the gag requirement for transformation of lymphoid cells by Abelson murine leukemia virus [PDF]

open access: yes, 1985
The single protein encoded by Abelson murine leukemia virus is a fusion of sequence from the retroviral gag genes with the v-abl sequence. Deletion of most of the gag region from the transforming protein results in a virus capable of transforming ...
Baltimore, David   +3 more
core  

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

open access: yesAdvanced Science, EarlyView.
This study reports an innovative strategy to improve the safety of OMVs by shielding them with a sophisticated shell composed of DaFe shell and Au nanoparticles, which not only reduces the toxicity of OMVs during circulation but also enables rapid release of these therapeutically active components in tumor for combined therapy involving glucose ...
Fan Zhang   +11 more
wiley   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

open access: yesAdvanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang   +5 more
wiley   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

open access: yesAdvanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang   +5 more
wiley   +1 more source

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