Results 141 to 150 of about 104,144 (317)

Mechanisms driving functional divergence of transcription factor paralogs

New Phytologist, EarlyView.
Summary Transcription factors (TFs) are core components of the regulatory toolkits that control gene expression. The sophistication of these regulatory toolkits dramatically increased during Eukaryotic evolution, accomplished in part by the duplication of existing TFs and the subsequent repurposing of these new paralogs. This process, termed functional
Isabella J. Higgins, Sarah G. Choudury, Aman Y. Husbands   +2 more
wiley   +1 more source

The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis

Scientific Reports, 2019
Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state.
S. Ashraf, M. Radhi, Peter R W Gowler, J. Burston, Raj Gandhi, G. J. Thorn, A. Piccinini, D. Walsh, V. Chapman, C. D. de Moor   +9 more
semanticscholar   +1 more source

A Comprehensive RNA-seq Analysis of Human Bocavirus 1 Transcripts in Infected Human Airway Epithelium

Viruses, 2019
Human bocavirus 1 (HBoV1) infects well-differentiated (polarized) human airway epithelium (HAE) cultured at an air-liquid interface (ALI). In the present study, we applied next-generation RNA sequencing to investigate the genome-wide transcription ...
Wei Zou, Min Xiong, Xuefeng Deng, John F. Engelhardt, Ziying Yan, Jianming Qiu   +5 more
doaj   +1 more source

RNA elements and their biotechnological applications in plants

New Phytologist, EarlyView.
Summary Engineering of plants for improved traits and efficient heterologous protein production can be achieved by modifying or introducing cis‐ or trans‐acting RNA elements. The function of these elements depends not only on their nucleotide sequence but also on their highly dynamic higher order structures.
Filip Lastovka, Hadrien Peyret, George P. Lomonossoff, Betty Y.‐W. Chung   +3 more
wiley   +1 more source

mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases

Genes and Diseases, 2023
The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Siyao Guo, Shuibin Lin
doaj  

Sequence determinants in human polyadenylation site selection

BMC Genomics, 2003
Background Differential polyadenylation is a widespread mechanism in higher eukaryotes producing mRNAs with different 3' ends in different contexts. This involves several alternative polyadenylation sites in the 3' UTR, each with its specific strength ...
Gautheret Daniel, Legendre Matthieu
doaj   +1 more source

Degradation of Hypomodified tRNA\u3csub\u3ei\u3c/sub\u3e\u3csup\u3eMet\u3c/sup\u3e in vivo Involves RNA-dependent ATPase Activity of the DExH Helicase Mtr4p [PDF]

, 2008
Effective turnover of many incorrectly processed RNAs in yeast, including hypomodified tRNAi Met, requires the TRAMP complex, which appends a short poly(A) tail to RNA designated for decay. The poly(A) tail stimulates degradation by the exosome.
Anderson, James T., Jankowsky, Eckhard, Jia, Huijue, Wang, Xuying   +3 more
core   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system [PDF]

, 2014
The regulated head-to-tail expression of Hox genes provides a coordinate system for the activation of specific programmes of cell differentiation according to axial level.
Akam, Alonso, Alonso, Alonso, Alonso, Arendt, Artero, Bardet, Beckervordersandforth, Bomze, Brudno, Cairrao, Custodio, Custodio, de la Mata, de Navas, Di Giammartino, Dittrich, Good, Halter, Hatton, Hilgers, Irvine, Kornfeld, Koushika, Licatalosi, Lisbin, Lopez, Lumsden, Lumsden, López de Silanes, Mallo, Mann, McGinnis, Miguel-Aliaga, O'Connor, Patraquim, Philippidou, Proudfoot, Reed, Reichert, Robinow, Robinow, Robinow, Rogulja-Ortmann, Schindelin, Schwartz, Shimell, Simon, Simone, Soller, Soller, Subramaniam, Sánchez-Herrero, Thomsen, Thor, Wang, Yao   +57 more
core   +1 more source

N6‐methyladenosine RNA modification regulates light intensity‐dependent terpenoid biosynthesis in Schizonepeta tenuifolia

Plant Biotechnology Journal, EarlyView.
Summary Schizonepeta tenuifolia Briq. (S. tenuifolia) is a traditional Chinese medicinal plant widely used to treat colds, fever and respiratory diseases. Volatile oils including the monoterpenoids limonene, pulegone and menthone are major constituents of S. tenuifolia that determine its medicinal value and consumer popularity.
Man Zhang, Qingyi Zhang, Zhirong Chen, Shuqi Wen, Yinhong Feng, Sujuan Duan, Hong‐Bin Wang, Hong‐Lei Jin   +7 more
wiley   +1 more source