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Full-Length Transcriptome Analysis of Alternative Splicing and Polyadenylation in the Molecular Regulation of Labor Division in <i>Apis cerana cerana</i>. [PDF]
Int J Mol SciYao D +5 more
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The bidirectional interplay between RNA processing and mechanotransduction. [PDF]
Cell RepBais GB, Giudice J.
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Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer. [PDF]
Cell Death DisLv J +17 more
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Alternative polyadenylation regulation: insights from sequential polyadenylation
Transcription, 2022The processing of the proximal and distal poly(A) sites in alternative polyadenylation (APA) has long been thought to independently occur on pre-mRNAs during transcription. However, a recent study by our groups demonstrated that the proximal sites for many genes could be activated sequentially following the distal ones, suggesting a multi-cleavage-same-
Peng Tang, Yu Zhou
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Cytoplasmic Polyadenylation Assays
2014Basic research in Drosophila melanogaster has benefited from a plethora of powerful genetics tools. Detailed biochemical analysis, however, has often been difficult due to the lack of in vitro systems that faithfully recapitulate the observations made in vivo.
Olga, Coll +2 more
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The biochemistry of polyadenylation
Trends in Biochemical Sciences, 1996During the synthesis of mRNA in the nucleus, 3'-ends are generated by endonucleolytic cleavage followed by polyadenylation. The machinery responsible for this simple reaction is surprisingly complex. In vitro reconstitution of 3'-end processing has demonstrated the importance of cooperative interactions in RNA recognition and catalysis.
Wahle, E., Keller, W.
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Cleavage of the polyadenylate-rich region of polyadenylate-rich RNA
Biochemical and Biophysical Research Communications, 1972Abstract The polyadenylate-rich portion of rapidly-labeled polyribosomal RNA isolated from lymphocytes or adrenal cortex was cleaved by a ribonuclease co-purifying with this RNA and retaining activity despite exposure to SDS and phenol. A ribosomal factor which inhibited the digestion of polyriboadenylate-rich RNA by the associated ribonuclease was ...
M G, Rosenfeld +2 more
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Developmental profile of polyadenylated and non-polyadenylated GABAA receptor subunit mRNAs
Molecular Brain Research, 1992The ratio of mRNA not selected for polyadenylation (non-poly(A)+ selected) to mRNA selected for polyadenylation (poly(A)+) for the beta 1, alpha 1 and gamma 2 subunits of the GABAA receptor complex was examined in rats as a function of age. RNA was extracted from whole brain of rats that were either 0, 1, 3, 5 or over 60 days of postnatal age. Poly(A)+
R J, Primus, A A, Jacobs, D W, Gallager
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Regulation of Retroviral Polyadenylation
2013Cellular and viral preRNAs are extensively cotranscriptionally modified. These modifications include the processing of the 3' end. Most preRNAs are polyadenylated, which is required for nuclear export, RNA stability, and efficient translation. Integrated retroviral genomes are flanked by 3' and 5' long terminal repeats (LTRs).
Eva-Maria, Schrom +3 more
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Bacteriophage T7 mRNA is polyadenylated
Molecular Microbiology, 1998To determine whether the RNA of bacterial viruses is polyadenylated like bacterial mRNAs, pulse‐labelled as well as the steady‐state population of bacteriophage T7‐specific transcripts were examined for the presence of poly(A) tracts by binding to oligo(dT) cellulose followed by hybridization with specific gene probes. Representatives of all classes of
M D, Johnson +4 more
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