Results 191 to 200 of about 62,357 (236)

End of the line: a kinetic ruler model for poly(A) tail termination. [PDF]

Genes Dev
Corbett AH.
europepmc   +1 more source

Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism. [PDF]

Circ Res
Witmer NH, Hoeger JM, McLendon JM, Stein CS, Yoon JY, Wang L, Berezhnaya E, Elrod JW, Knollmann BC, London B, Boudreau RL.   +10 more
europepmc   +1 more source

Molecular features of a Huntington's disease knock-in minipig. [PDF]

Dis Model Mech
Kolesnikova A, Sathasivam K, Tusi SK, Landles C, Osborne GF, Kovalenko M, Gillis T, Kamenná E, Sekáč D, Nguyen DT, Valeková I, Juhás Š, Juhásová J, Levinská B, Baxa M, Motlík J, Klíma J, Howland D, Wheeler VC, Bates GP, Ellederova Z.   +20 more
europepmc   +1 more source

[Role of polyadenylic segments and RNA polyadenylation in embryonic development].

Postepy biochemii, 1986
openaire   +1 more source

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Alternative polyadenylation regulation: insights from sequential polyadenylation

Transcription, 2022
The processing of the proximal and distal poly(A) sites in alternative polyadenylation (APA) has long been thought to independently occur on pre-mRNAs during transcription. However, a recent study by our groups demonstrated that the proximal sites for many genes could be activated sequentially following the distal ones, suggesting a multi-cleavage-same-
Peng Tang, Yu Zhou
openaire   +2 more sources

The biochemistry of polyadenylation

Trends in Biochemical Sciences, 1996
During the synthesis of mRNA in the nucleus, 3'-ends are generated by endonucleolytic cleavage followed by polyadenylation. The machinery responsible for this simple reaction is surprisingly complex. In vitro reconstitution of 3'-end processing has demonstrated the importance of cooperative interactions in RNA recognition and catalysis.
Wahle, E., Keller, W.
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Cleavage of the polyadenylate-rich region of polyadenylate-rich RNA

Biochemical and Biophysical Research Communications, 1972
Abstract The polyadenylate-rich portion of rapidly-labeled polyribosomal RNA isolated from lymphocytes or adrenal cortex was cleaved by a ribonuclease co-purifying with this RNA and retaining activity despite exposure to SDS and phenol. A ribosomal factor which inhibited the digestion of polyriboadenylate-rich RNA by the associated ribonuclease was ...
M G, Rosenfeld, I B, Abrass, L A, Perkins   +2 more
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Polyadenylation in Bacteria and Organelles

2014
Polyadenylation is a posttranscriptional modification present throughout all the kingdoms of life with important roles in regulation of RNA stability, translation, and quality control. Functions of polyadenylation in prokaryotic and organellar RNA metabolism are still not fully characterized, and poly(A) tails appear to play contrasting roles in ...
Joanna, Rorbach, Agnieszka, Bobrowicz, Sarah, Pearce, Michal, Minczuk   +3 more
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Regulation of Retroviral Polyadenylation

2013
Cellular and viral preRNAs are extensively cotranscriptionally modified. These modifications include the processing of the 3' end. Most preRNAs are polyadenylated, which is required for nuclear export, RNA stability, and efficient translation. Integrated retroviral genomes are flanked by 3' and 5' long terminal repeats (LTRs).
Eva-Maria, Schrom, Rebecca, Moschall, Anita, Schuch, Jochen, Bodem   +3 more
openaire   +2 more sources