Insulin-like growth factor-1 induces hyperproliferation of PKD1 cystic cells via a Ras/Raf dependent signalling pathway [PDF]
, 2007 Autosomal dominant polycystic kidney disease (ADPKD) largely results from mutations in the PKD1 gene leading to hyperproliferation of renal tubular epithelial cells and consequent cyst formation.
Harris, P.C. +7 more
core +1 more source
Autopsy and Case Reports, 2020 We describe an autopsy case of a 45-year-old male diagnosed with autosomal dominant polycystic kidney disease who presented with complaints of altered sensorium.
Arpitha Kollabathula +6 more
doaj +1 more source
An excess of gene expression divergence on the X chromosome in Drosophila embryos; implications for the faster-X hypothesis [PDF]
PLoS Genetics (2012)8(12):e1003200, 2012 The X chromosome is present as a single copy in the heterogametic sex, and this hemizygosity is expected to drive unusual patterns of evolution on the X relative to the autosomes. For example, the hemizgosity of the X may lead to a lower chromosomal effective population size compared to the autosomes suggesting that the X might be more strongly ...
arxiv +1 more source
External iliac artery dissection during kidney transplant for polycystic kidney disease : a caveat for surgeons [PDF]
, 2018 Autosomal dominant polycystic kidney disease is a common cause of end-stage renal failure and an indication for transplant. The genetic mutation in autosomal dominant polycystic kidney disease also causes vascular abnormalities, mainly aneurysms but
Karusseit, V.O.L. (Otto)
core +1 more source
Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior [PDF]
, 2003 Caenorhabditis elegans polycystins LOV-1 and PKD-2 are expressed in the male-specific HOB neuron, and are necessary for sensation of the hermaphrodite vulva during mating. We demonstrate that male vulva location behavior and expression of lov-1 and pkd-2
Bürglin, Thomas R. +3 more
core +1 more source
Case Reports in Gastrointestinal Medicine, 2014 Polycystic liver disease (PLD) is a hereditary disease inherited by autosomal dominant trait that occurs as a frequent extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD).
Patricia Ramírez de la Piscina +11 more
doaj +1 more source
De-biased lasso for stratified Cox models with application to the national kidney transplant data [PDF]
arXiv, 2022 The Scientific Registry of Transplant Recipients (SRTR) system has become a rich resource for understanding the complex mechanisms of graft failure after kidney transplant, a crucial step for allocating organs effectively and implementing appropriate care.
arxiv
p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. [PDF]
, 2007 BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts
Anderson, Sharon +6 more
core +3 more sources
Advances in Autosomal Dominant Polycystic Kidney Disease: A Clinical Review
Kidney Medicine, 2020 Polycystic kidney disease (PKD) is a multiorgan disorder resulting in fluid-filled cyst formation in the kidneys and other systems. The replacement of kidney parenchyma with an ever-increasing volume of cysts eventually leads to kidney failure. Recently,
Niloofar Nobakht +7 more
doaj
Metabolism-based approaches for autosomal dominant polycystic kidney disease
Frontiers in Molecular Biosciences, 2023 Autosomal Dominant Polycystic Kidney Disease (ADPKD) leads to end stage kidney disease (ESKD) through the development and expansion of multiple cysts throughout the kidney parenchyma.
Ivona Bakaj, Alessandro Pocai
doaj +1 more source