Results 71 to 80 of about 30,345 (207)

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16 [PDF]

, 1994
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder that frequently results in renal fallure due to progressive cyst development. The major locus, PKD1, maps to 16p13.3.
Breuning, M.H. (Martijn), Brook-Carter, P.T. (Phillip), Buckle, P. (Peter), Cabral, P. (Pedro), Cordeiro, I. (Isabel), Dauwerse, H.G. (Hans), Eussen, H.J.F.M.M. (Bert), Gamble, V. (Vicki), Halley, D.J.J. (Dicky), Harris, P.C. (Peter), Hesseling-Janssen, A.L.W. (Arjenne), Higgs, D. (Douglas), Hughes, J. (Jim), Janssen, L.A.J. (Bart), Kearney, P. (Peter), Lindhout, D. (Dick), MacCarthy, A.B. (Angela), Maheshwar, M.M. (Magitha), Nellist, M.D. (Mark), Ouweland, A.M.W. (Ans) van den, Peral, B. (Belén), Peters, D. (Dorien), Ratcliffe, C., Roelfsema, J.H. (Jeroen), Sampson, J. (Julian), Santos, H. (Heloisa), Saris, J.J. (Jasper), Sloane-Stanley, J. (Jackie), Spruit, L. (Lia), Thomas, S. (Siep), Verhoef, S., Ward, C.J. (Christopher)   +31 more
core   +1 more source

Real‐World Effectiveness of Tolvaptan for Hyponatremia in Cirrhosis Across Global Regions: A Target Trial Emulation

JGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Background Tolvaptan promotes electrolyte‐free water excretion and is widely used in Asia for ascites, but in Western countries its use is limited to hyponatremia because of hepatotoxicity concerns. Methods We performed a retrospective cohort study using the TriNetX Research Network, emulating a target trial of cirrhotic patients with ...
Kazuya Okushin, Ryosuke Tateishi, Mitsuhiro Fujishiro, Takeya Tsutsumi, Kazuhiko Koike, Tomohiro Tanaka   +5 more
wiley   +1 more source

Pain in Autosomal Dominant Polycystic Kidney Disease [PDF]

European Medical Journal Nephrology, 2014
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder affecting 1 in 1,000 people and is responsible for 10% of cases of end-stage renal disease.
Mariusz Niemczyk
doaj  

Polycystic kidney disease in a Persian cat [PDF]

, 2015
A 6-year-old intact Persian cat was presented for the primary complaint of inappetence and weight loss. Irregular surface of kidneys was palpated during physical examination. Abdominal radiograph findings were indicative of renomegaly.
Khor, Kuan Hua, Lau, Seng Fong, Phoon, Melissa Hoi Ee, Saw, Ming Hooi   +3 more
core  

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging

VIEW, Volume 7, Issue 2, April 2026.
Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao, Jingyu Deng, Qin Li, Tong Xia, Xun Yang, Simei Yang, Changzhen Sun, Xia Xiong, Li Liu   +8 more
wiley   +1 more source

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 ...
Bourgeois, Bryan C, Kruger, Samantha L, Shillingford, Jonathan M, Torres, Jacob, Weimbs, Thomas   +4 more
core   +1 more source

Hepatic Cyst Infection During Use of the Somatostatin Analog Lanreotide in Autosomal Dominant Polycystic Kidney Disease: An Interim Analysis of the Randomized Open-Label Multicenter DIPAK-1 Study [PDF]

, 2017
Introduction and Aims: The DIPAK-1 Study investigates the reno- and hepatoprotective efficacy of the somatostatin analog lanreotide compared with standard care in patients with later stage autosomal dominant polycystic kidney disease (ADPKD). During this
Casteleijn, E. (Eric), de Fijter, J.W. (Johan W.), Drenth, J.P.H., Drenth, J.P.H. (Joost), D’Agnolo, H.M.A. (Hedwig M. A.), Fijter, J.W. (Johan) de, Gansevoort, R.T., Gansevoort, R.T. (Ron), Lantinga, M.A. (Marten A.), Meijer, E. (Esther), Messchendorp, A.L. (A. Lianne), Peters, D. (Dorien), Peters, D.J.M. (Dorien J.M.), Salih, M. (Mahdi), Soonawala, D. (Darius), Spithoven, E.M. (Edwin), Visser, F.W. (Folkert), Wetzels, J.F.M. (Jack F. M.), Wetzels, J.F.M. (Jack), Zietse, R., Zietse, R. (Bob)   +20 more
core   +1 more source

A Retrospective Cross‐Sectional Study of 142 Patients in a Multidisciplinary Tuberous Sclerosis Clinic

Clinical Genetics, Volume 109, Issue 4, Page 697-706, April 2026.
We found key differences between tuberous sclerosis patients with TSC1 and TSC2 variants. Patients carrying TSC2 variants had more severe and earlier‐onset symptoms. We also identified two distinct clinical subgroups which follow different disease courses: one characterized by predominant renal involvement and the other by more pronounced neurological ...
Hila Weisblum Neuman, Sara Via Dorembus, Omer Shlomovitz, Shoshana Greenberger, Einat Lahav, Sharon Mini‐Goldberger, Michal Tzadok   +6 more
wiley   +1 more source

Building a network of ADPKD reference centres across Europe: the EuroCYST initiative [PDF]

, 2016
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic inherited kidney disease, affecting an estimated 600 000 individuals in Europe. The disease is characterized by age-dependent development of a multiple cysts in
Budde, Klemens, Chaveau, Dominique, Devuyst, Olivier, Ecder, Tevfik, Eckardt, Kai-Uwe, Gansevoort, Ron T., Köttgen, Anna, Le Meur, Yannick, Ong, Albert C M., Petzold, Katja, Pirson, Yves, Remuzzi, Giuseppe, Rotar, Laura, Sandford, Richard, Serra, Andreas L., Tesar, Vladimir, Torra, Roser, Wüthrich, Rudolf P.   +17 more
core   +2 more sources