Results 81 to 90 of about 43,386 (236)

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 ...
Bourgeois, Bryan C, Kruger, Samantha L, Shillingford, Jonathan M, Torres, Jacob, Weimbs, Thomas   +4 more
core   +1 more source

Autosomal dominant polycystic kidney disease. [PDF]

Journal of the American Society of Nephrology, 1993
Autosomal dominant polycystic kidney disease (ADPKD) is an important cause of medical morbidity in the United States that affects one-half million persons and accounts for ESRD in about 10% of the chronic dialysis population. In addition to its effects on the kidney, the disease has important manifestations in the cardiovascular system (aneurysms ...
J C, Lieske, F G, Toback
openaire   +2 more sources

Assessing the Impact of Imaging Parameters on MRI Measurement of Kidney T2

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 508-522, February 2026.
ABSTRACT Background T2‐mapping has promise to evaluate kidney pathophysiology. Prior studies show a large variance in kidney T2, likely due to the differing acquisition sequences. Purpose To compare four T2‐mapping sequences to investigate kidney T2. Study Type Phantom and prospective in vivo assessments.
Alexander J. Daniel, Susan T. Francis
wiley   +1 more source

Advantage of Sleeve Right Lower Lobectomy for Lung Cancer in COPD Patients: A Case Series

Thoracic Cancer, Volume 17, Issue 3, February 2026.
Sleeve right lower lobectomy (SRLL) may preserve postoperative pulmonary function better than standard procedures in selected lung cancer patients with COPD. This approach could be a useful surgical option when both oncologic safety and lung function preservation are prioritized. ABSTRACT Sleeve right lower lobectomy (SRLL) is an uncommon procedure for
Yuzu Harata, Shinogu Takashima, Nobuyasu Kurihara, Shoji Kuriyama, Satoshi Kudo, Ryo Demura, Haruka Suzuki, Kazuhiro Imai   +7 more
wiley   +1 more source

A novel PKD1 variant demonstrates a disease-modifying role in trans with a truncating PKD1 mutation in patients with Autosomal Dominant Polycystic Kidney Disease [PDF]

, 2015
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common form of Polycystic Kidney Disease (PKD) and occurs at a frequency of 1/800 to 1/1000 affecting all ethnic groups worldwide.
Al-Mulla, Fahd, Ali, Hamad, Harris, Peter, Hussain, Naser, Kehinde, Elijah, Naim, Medhat, Seaburg, Lauren, Sundsbak, Jamie, Zayed, Mohamed   +8 more
core  

Epidemiology of Autosomal Dominant Polycystic Kidney Disease in Olmsted County.

American Society of Nephrology. Clinical Journal, 2019
BACKGROUND AND OBJECTIVES The prevalence of autosomal dominant polycystic kidney disease (ADPKD) remains controversial. Incidence rates in Olmsted County, Minnesota, during 1935-1980 were previously reported. The current work extends this study to 2016.
Tatsuya Suwabe, Shehbaz Shukoor, A. Chamberlain, J. Killian, B. King, Marie E. Edwards, Sarah R. Senum, Charles D. Madsen, F. Chebib, M. Hogan, E. Cornec-Le Gall, P. Harris, V. Torres   +12 more
semanticscholar   +1 more source

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source

Relevance of ultrasound examination in general practice. A case report of a patient with autosomal dominant polycystic kidney disease

Journal of Ultrasonography, 2013
Autosomal dominant polycystic kidney disease is a genetic disorder which results in the development of multiple cysts in the kidneys and other parenchymal organs. The two genes in which mutations are known to cause autosomal dominant polycystic kidney
Izabela Cwojdzińska-Jankowska, Anna Plewa   +1 more
doaj  

T1 vs. T2 weighted magnetic resonance imaging to assess total kidney volume in patients with autosomal dominant polycystic kidney disease [PDF]

, 2017
Purpose: In ADPKD patients total kidney volume (TKV) measurement using MRI is performed to predict rate of disease progression. Historically T1 weighted images (T1) were used, but the methodology of T2 weighted imaging (T2) has evolved.
A. Lianne Messchendorp, Gert J. ter Horst, Maatje D. A. van Gastel, Marissa de Jong, Merel A. Kaatee, null null, Peter Kappert, Remco J. Renken, Ron T. Gansevoort, Shekar V. K. Mahesh   +9 more
core   +1 more source

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model

Nature Communications, 2019
The human PKD2 locus encodes Polycystin-2 (PC2), a TRPP channel that localises to several distinct cellular compartments, including the cilium. PKD2 mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD) and affect many cellular pathways ...
R. Walker, J. Keynton, D. Grimes, V. Sreekumar, Debbie J. Williams, C. Esapa, Dongsheng Wu, M. Knight, D. Norris   +8 more
semanticscholar   +1 more source