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Polycystic kidney disease [PDF]

Nature Reviews Disease Primers, 2018
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases.
Bergmann, C., Guay-Woodford, L.M., Harris, P.C., Horie, S., Peters, D.J.M., Torres, V.E.   +5 more
semanticscholar   +8 more sources

Coronary aneurysms and dissections in a patient with autosomal dominant polycystic kidney disease: a case report [PDF]

Journal of Medical Case Reports
Background Autosomal dominant polycystic kidney disease is the most common hereditary kidney disorder, characterized by the progressive formation of renal cysts due to genetic mutations.
Maria Júlia Carnieletto Nicolodi, Gustavo Carnieletto Garcia, Md. José Knopfholz   +2 more
doaj   +2 more sources

Polycystic Kidney Disease [PDF]

Journal of the American Society of Nephrology, 2007
Renal cysts are common clinical findings, often incidentally discovered in the course of evaluating other problems. They may be either acquired or seen in association with a number of inherited and congenital disorders. The most common disorder, autosomal dominant polycystic kidney disease (ADPKD), is an important cause of end-stage renal disease (ESRD)
Peter, Igarashi, Stefan, Somlo
  +6 more sources

Polycystic Kidney Disease [PDF]

Annual Review of Medicine, 2009
A number of inherited disorders result in renal cyst development. The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed in adults and caused by mutation in PKD1 or PKD2. The PKD1 protein, polycystin-1, is a large receptor-like protein, whereas polycystin-2 is a transient receptor potential ...
Peter C, Harris, Vicente E, Torres
  +7 more sources

Genome editing strategies to generate working models of polycystic kidney disease. [PDF]

Sci Rep
Migliorero M, Marsalla D, Vallone FE, Ragone A, Saglia C, Scolari C, Bracciamà V, Arruga F, Sorbini M, Faini AC, Peruzzi L, Vaisitti T, Deaglio S.   +12 more
europepmc   +3 more sources

Clinical characteristics and outcomes of hyponatraemia associated with oral water intake in adults: a systematic review

BMJ Open, 2021
Introduction Excessive water intake is rarely associated with life-threatening hyponatraemia. The aim of this study was to determine the clinical characteristics and outcomes of hyponatraemia associated with excess water intake.Methods This review was ...
Martin Howell, Anna Rangan, Gopala K Rangan, Nilofar Dorani, Miranda M Zhang, Lara Abu-Zarour, Ho Ching Lau, Alexandra Munt, Ashley N Chandra, Sayanthooran Saravanabavan, Jennifer Q J Zhang, Annette TY Wong   +11 more
doaj   +1 more source

Effect of Early and Delayed Commencement of Paricalcitol in Combination with Enalapril on the Progression of Experimental Polycystic Kidney Disease

Journal of Cardiovascular Development and Disease, 2021
Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. The aim of this study was to test the hypothesis that the vitamin D receptor agonist, paricalcitol (PC), either alone or with enalapril (E ...
Priyanka S. Sagar, Sayanthooran Saravanabavan, Alexandra Munt, Annette T. Y. Wong, Gopala K. Rangan   +4 more
doaj   +1 more source

An Empirical Biomarker-based Calculator for Autosomal Recessive Polycystic Kidney Disease - The Nieto-Narayan Formula [PDF]

, 2016
Autosomal polycystic kidney disease (ARPKD) is associated with progressive enlargement of the kidneys fuelled by the formation and expansion of fluid-filled cysts.
Goldberg, Itzhak D., Narayan, Prakash, Nieto, Jake A., Yamin, Michael A.   +3 more
core   +9 more sources

Polycystic Kidney Disease [PDF]

The Journal of Clinical Hypertension, 2005
Polycystic kidney disease, an inherited systemic disorder, is characterized by the development of multiple cysts in the kidneys and other organs. Patients can present at any age, but more often come to clinical attention (unless there is a family history) after age 30. Patients who are diagnosed before age 30 have a worse renal survival.
Pamela J, Fall, L Michael, Prisant
openaire   +4 more sources

Participant Perceptions in a Long-term Clinical Trial of Autosomal Dominant Polycystic Kidney Disease

Kidney Medicine, 2023
Rationale & Objective: The development of new therapies for autosomal dominant polycystic kidney disease requires clinical trials to be conducted efficiently. In this study, the factors affecting the recruitment and retention of participants enrolled
Sneha Amin, Irene Sangadi, Margaret Allman-Farinelli, Sunil V. Badve, Neil Boudville, Helen Coolican, Susan Coulshed, Sheryl Foster, Mangalee Fernando, Imad Haloob, David C.H. Harris, Carmel M. Hawley, Jane Holt, Martin Howell, Karthik Kumar, David W. Johnson, Vincent W. Lee, Jun Mai, Anna Rangan, Simon D. Roger, Kamal Sud, Vicente Torres, Eswari Vilayur, Gopala K. Rangan   +23 more
doaj   +1 more source