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Polycystic kidney disease [PDF]

Nature Reviews Disease Primers, 2017
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases.
C. Bergmann, L. Guay-Woodford, P. Harris, S. Horie, D. Peters, V. Torres   +5 more
semanticscholar   +13 more sources

Polycystic kidney disease

InnovAiT: Education and inspiration for general practice, 2020
Polycystic kidney disease (PKD) is a monogenic, hereditary disorder of the kidneys that leads to fluid-filled cysts within the renal tubes. It is one of the most common causes of end-stage renal failure.
Soo Oh, Rabeet Khan, Ahmed Ziada
semanticscholar   +3 more sources

MicroRNAs and Polycystic Kidney Disease [PDF]

Kidney Medicine, 2020
Important advances have been made regarding the diagnosis and management of polycystic kidney diseases. Care of patients with polycystic kidney diseases has moved beyond supportive care for complications and chronic kidney disease to new potentially ...
Dantong Li, Liangzhong Sun
doaj   +4 more sources

Participant Perceptions of Increasing Water Intake in Polycystic Kidney Disease [PDF]

Kidney International Reports
Introduction: Clinical practice guidelines suggest maintaining adequate hydration in people with autosomal dominant polycystic kidney disease (ADPKD). However, the long-term perceptions of increasing water intake and the role of self-efficacy tools are ...
Sneha Amin, Irene Sangadi, Margaret Allman-Farinelli, Neil Boudville, Imad Haloob, David C.H. Harris, Carmel M. Hawley, David W. Johnson, Vincent W. Lee, Jun Mai, Anna Rangan, Simon D. Roger, Kamal Sud, Eswari Vilayur, Gopala K. Rangan   +14 more
doaj   +1 more source

Complications of polycystic kidney disease

Kidney International, 1997
A 33-year-old white man first presented to the Royal Infirmary Stirling, Scotland, 24 years ago with a history of recent-onset hematuria. Intravenous urography at that time showed a filling defect in the right kidney; a subsequent aortogram demonstrated a single simple cyst in the right kidney.
Michael L. Watson
openalex   +4 more sources

Polycystic kidney disease

Kidney International, 1982
Principal discussant Wadi N. Suki
openalex   +4 more sources

Clinical characteristics and outcomes of hyponatraemia associated with oral water intake in adults: a systematic review

BMJ Open, 2021
Introduction Excessive water intake is rarely associated with life-threatening hyponatraemia. The aim of this study was to determine the clinical characteristics and outcomes of hyponatraemia associated with excess water intake.Methods This review was ...
Martin Howell, Anna Rangan, Gopala K Rangan, Nilofar Dorani, Miranda M Zhang, Lara Abu-Zarour, Ho Ching Lau, Alexandra Munt, Ashley N Chandra, Sayanthooran Saravanabavan, Jennifer Q J Zhang, Annette TY Wong   +11 more
doaj   +1 more source

Effect of Early and Delayed Commencement of Paricalcitol in Combination with Enalapril on the Progression of Experimental Polycystic Kidney Disease

Journal of Cardiovascular Development and Disease, 2021
Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. The aim of this study was to test the hypothesis that the vitamin D receptor agonist, paricalcitol (PC), either alone or with enalapril (E ...
Priyanka S. Sagar, Sayanthooran Saravanabavan, Alexandra Munt, Annette T. Y. Wong, Gopala K. Rangan   +4 more
doaj   +1 more source

Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease

Nature Genetics, 2022
Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a distinct CD24+ epithelial subpopulation.
Yaoxian Xu, C. Kuppe, J. Perales-Patón, Sikander Hayat, Jennifer Kranz, Ali T. Abdallah, J. Nagai, Zhijian Li, Fabian Peisker, Turgay Saritas, M. Halder, Sylvia Menzel, Konrad Hoeft, A. Kenter, Hyojin Kim, Claudia R C van Roeyen, M. Lehrke, J. Moellmann, T. Speer, E. Buhl, R. Hoogenboezem, P. Boor, J. Jansen, C. Knopp, I. Kurth, B. Smeets, E. Bindels, M. Reinders, C. Baan, J. Gribnau, E. Hoorn, J. Steffens, T. Huber, Ivan G. Costa, J. Floege, R. Schneider, J. Saez-Rodriguez, Benjamin S. Freedman, R. Kramann   +38 more
semanticscholar   +1 more source

Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial

Trials, 2023
Background In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide (NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice (BRJ) reduces blood pressure (BP) by increasing NO-mediated vasodilation. The aim of
Priyanka S. Sagar, Alexandra Munt, Sayanthooran Saravanabavan, Farnoosh Asghar Vahedi, James Elhindi, Beatrice Nguyen, Katrina Chau, David C. Harris, Vincent Lee, Kamal Sud, Nikki Wong, Gopala K. Rangan   +11 more
doaj   +1 more source