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Polycystic Kidney Disease [PDF]
New England Journal of Medicine, 1989 The Polycystic Kidney Disease (PKD) is a genetic disease which is characterized by the gradual emergence of cystic lesions in the kidneys, which replace the renal parenchyma causing deterioration of its function to stage 5. The PKD is one of the causes of Chronic Kidney Disease on renal replacement therapy (RRT).
Lavie, C.J. +3 more
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AMPK and Polycystic Kidney Disease Drug Development: An Interesting Off-Target Target
Frontiers in Medicine, 2022 Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes dramatic perturbations of both renal tissue architecture and of a multitude of cellular signaling pathways.
Michael J. Caplan
doaj +1 more source
Polycystic Kidney Disease [PDF]
Pediatrics In Review, 2009 1. Jacques Benun, MD 2. Carol Lewis, MD 1. Hasbro Children's Hospital Providence, RI Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD): The New Horizon For Children Who Have DPKD . Rizk D, Chapman A. Pediatr Nephrol. 2008;23 :1029– 1036[OpenUrl][1][CrossRef][2][PubMed][3] Autosomal Recessive Polycystic Kidney Disease ...
Carol Lewis, Jacques Benun
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Polycystic Kidney Disease [PDF]
Journal of the American Society of Nephrology, 2007 Renal cysts are common clinical findings, often incidentally discovered in the course of evaluating other problems. They may be either acquired or seen in association with a number of inherited and congenital disorders. The most common disorder, autosomal dominant polycystic kidney disease (ADPKD), is an important cause of end-stage renal disease (ESRD)
Stefan Somlo, Peter Igarashi
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Health disparities in chronic liver disease
Hepatology, EarlyView., 2022 Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian +3 more
wiley +1 more source
Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients [PDF]
The Korean Journal of Internal Medicine, 2021 Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and
Yun Kyu Oh +4 more
doaj +1 more source
Atypical Polycystic Kidney Disease as defined by Imaging
Scientific Reports, 2023 Using age- and height-adjusted total kidney volume, the Mayo Clinic Imaging Classification provides a validated approach to assess the risk of chronic kidney disease (CKD) progression in autosomal dominant polycystic kidney disease (ADPKD), but requires ...
Ioan-Andrei Iliuta +13 more
doaj +1 more source
Journal of Cell Science, 2020 Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells ...
T. Vien +9 more
semanticscholar +1 more source
Polycystic Kidney Disease [PDF]
The Journal of Clinical Hypertension, 2005 Polycystic kidney disease, an inherited systemic disorder, is characterized by the development of multiple cysts in the kidneys and other organs. Patients can present at any age, but more often come to clinical attention (unless there is a family history) after age 30. Patients who are diagnosed before age 30 have a worse renal survival.
L. Michael Prisant, Pamela J. Fall
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Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.
American Society of Nephrology. Clinical Journal, 2020 Autosomal dominant polycystic kidney disease is the most common monogenic cause of ESKD. Genetic studies from patients and animal models have informed disease pathobiology and strongly support a "threshold model" in which cyst formation is triggered by ...
M. Lanktree +4 more
semanticscholar +1 more source