Results 31 to 40 of about 488,068 (360)
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
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Unilateral polycystic kidney disease [PDF]
American Journal of Roentgenology, 1978 Although involvement of the kidneys by the adult form of polycystic kidney disease may be asynchronous or asymmetric, the disorder is thought of as invariably bilateral according to some pathologists [1]. Scattered cases of unilateral polycystic kidney disease have been reported in the urobogic but not the radiobogic literature.
J K, Lee, B L, McClennan, J M, Kissane
openaire +2 more sources
Kidney Medicine, 2019 Light chain proximal tubulopathy is a rare M-proteinemia–related nephropathy. The inclusions, composed of light chains in light chain proximal tubulopathy, are generally crystalline, and most exhibit a rhombic shape.
Ayami Ino +8 more
doaj +1 more source
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]
, 2006 PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E. +4 more
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TNF-α blockade is ineffective in animal models of established polycystic kidney disease [PDF]
, 2013 BACKGROUND: Given the large medical burden of polycystic kidney disease (PKD) and recent clinical trial failures, there is a need for novel, safe and effective treatments for the disorder.
Jeffrey Roix, Saurabh Saha
core +2 more sources
Autosomal recessive polycystic kidney disease [PDF]
Nephrology Dialysis Transplantation, 1996 Autosomal recessive polycystic kidney disease (ARPKD) is a rare inherited disorder which usually becomes clinically manifest in early childhood. With increasing knowledge and improving diagnostic techniques it has become evident that the spectrum of ARPKD is much more variable than was previously thought.
K, Zerres +3 more
openaire +3 more sources
Improved Structure and Function in Autosomal Recessive Polycystic Rat Kidneys with Renal Tubular Cell Therapy. [PDF]
PLoS ONE, 2015 Autosomal recessive polycystic kidney disease is a truly catastrophic monogenetic disease, causing death and end stage renal disease in neonates and children.
K J Kelly +6 more
doaj +1 more source
Combined liver-kidney transplant in polycystic diseases: a case report [PDF]
Einstein (São Paulo), 2023 Polycystic liver disease, a hereditary pathology, usually manifests as autosomal dominant polycystic kidney disease. The many cysts in the liver cause massive hepatomegaly, majorly affecting the patient’s quality of life. In cases of refractory symptoms,
Olival Cirilo Lucena da Fonseca Neto +7 more
doaj +1 more source
MicroRNAs and Polycystic Kidney Disease [PDF]
Drug Discovery Today: Disease Models, 2013 Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to retard cyst growth.
Lama, Noureddine +2 more
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Nature Communications, 2019 Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the leading genetic cause of end-stage renal disease.
Edmund C. Lee +25 more
semanticscholar +1 more source