Kidney transcriptome and cystic kidney disease genes in zebrafish
Frontiers in Physiology, 2023 Introduction: Polycystic kidney disease (PKD) is a condition where fluid filled cysts form on the kidney which leads to overall renal failure. Zebrafish has been recently adapted to study polycystic kidney disease, because of its powerful embryology and ...
Matthew Koslow +5 more
doaj +1 more source
Modeling Vascular Branching Alterations in Polycystic Kidney Disease [PDF]
arXiv, 2022 The analysis of biological networks encompasses a wide variety of fields from genomic research of protein-protein interaction networks, to the physiological study of biologically optimized tree-like vascular networks. It is certain that different biological networks have different optimization criteria and we are interested in those networks optimized ...
arxiv
Identification, Characterization, and Localization of a Novel Kidney Polycystin-1-Polycystin-2 Complex [PDF]
, 2002 The functions of the two proteins defective in autosomal dominant polycystic kidney disease, polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that they may heterodimerize to form a "polycystin complex" involved ...
Ackermann +43 more
core +1 more source
Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]
, 2016 Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro +2 more
core +1 more source
Polycystic kidney disease complicates renal pathology in a family with Fabry disease
Molecular Genetics and Metabolism Reports, 2022 Fabry disease is a rare lysosomal storage disorder that primarily affects the heart and kidneys, often presenting with reduced renal function. Polycystic kidney disease is a renal condition in which cysts are found, which have a different presentation ...
Leepakshi Johar +7 more
doaj
De-biased lasso for stratified Cox models with application to the national kidney transplant data [PDF]
arXiv, 2022 The Scientific Registry of Transplant Recipients (SRTR) system has become a rich resource for understanding the complex mechanisms of graft failure after kidney transplant, a crucial step for allocating organs effectively and implementing appropriate care.
arxiv
TNF-α blockade is ineffective in animal models of established polycystic kidney disease [PDF]
, 2013 BACKGROUND: Given the large medical burden of polycystic kidney disease (PKD) and recent clinical trial failures, there is a need for novel, safe and effective treatments for the disorder.
Jeffrey Roix, Saurabh Saha
core +2 more sources
European Medical Journal Urology, 2020 Horseshoe kidney is the most common renal fusion anomaly occurring in 0.15–0.25% of the general population. Horseshoe kidney is usually asymptomatic but may present with disease-like infections, urolithiasis, malignancy, polycystic disease, and other ...
Ayun Cassell +9 more
doaj +1 more source
Role of Image Acquisition and Patient Phenotype Variations in Automatic Segmentation Model Generalization [PDF]
arXiv, 2023 Purpose: This study evaluated the out-of-domain performance and generalization capabilities of automated medical image segmentation models, with a particular focus on adaptation to new image acquisitions and disease type. Materials: Datasets from both non-contrast and contrast-enhanced abdominal CT scans of healthy patients and those with polycystic ...
arxiv
Liver Transplantation for Polycystic Liver Disease [PDF]
, 1990 Four female patients with severe complications of polycystic liver disease were treated with liver replacement; two patients were also given kidneys from their liver donors. All four of the patients were suffering from extreme fatigue.
Gordon, R +5 more
core +1 more source