Results 51 to 60 of about 462,629 (365)

Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury [PDF]

, 2009
Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there are
Haylor, J.L., McDaid, J.P., Ong, A.C.M., Prasad, S., Tam, F.W.K.   +4 more
core   +2 more sources

Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature

Journal of Medical Case Reports, 2010
Introduction Autosomal dominant polycystic kidney disease is an inherited disorder that is characterized by the development and growth of cysts in the kidneys and other organs.
Kapoor Vinay, Minz Ranjana, Kaur Ravinder, Mohan Harsh, Singh Rajdeep, D'Cruz Sanjay, Sachdev Atul   +6 more
doaj   +1 more source

Kidney transcriptome and cystic kidney disease genes in zebrafish

Frontiers in Physiology, 2023
Introduction: Polycystic kidney disease (PKD) is a condition where fluid filled cysts form on the kidney which leads to overall renal failure. Zebrafish has been recently adapted to study polycystic kidney disease, because of its powerful embryology and ...
Matthew Koslow, Ping Zhu, Chantal McCabe, Xiaolei Xu, Xiaolei Xu, Xueying Lin   +5 more
doaj   +1 more source

TNF-α blockade is ineffective in animal models of established polycystic kidney disease [PDF]

, 2013
BACKGROUND: Given the large medical burden of polycystic kidney disease (PKD) and recent clinical trial failures, there is a need for novel, safe and effective treatments for the disorder.
Jeffrey Roix, Saurabh Saha
core   +2 more sources

Polycystic kidney disease complicates renal pathology in a family with Fabry disease

Molecular Genetics and Metabolism Reports, 2022
Fabry disease is a rare lysosomal storage disorder that primarily affects the heart and kidneys, often presenting with reduced renal function. Polycystic kidney disease is a renal condition in which cysts are found, which have a different presentation ...
Leepakshi Johar, Grace Lee, Angela Martin-Rios, Kathy Hall, Cheng Cheng, Dawn Lombardo, Madeleine Pahl, Virginia Kimonis   +7 more
doaj  

Liver Transplantation for Polycystic Liver Disease [PDF]

, 1990
Four female patients with severe complications of polycystic liver disease were treated with liver replacement; two patients were also given kidneys from their liver donors. All four of the patients were suffering from extreme fatigue.
Gordon, R, Mieles, L, Reyes, J, Starzl, TE, Todo, S, Tzakis, A   +5 more
core   +1 more source

Prevalence Estimates of Polycystic Kidney and Liver Disease by Population Sequencing.

Journal of the American Society of Nephrology, 2018
BACKGROUND Estimating the prevalence of autosomal dominant polycystic kidney disease (ADPKD) is challenging because of age-dependent penetrance and incomplete clinical ascertainment.
M. Lanktree, A. Haghighi, E. Guiard, Ioan-Andrei Iliuta, Xuewen Song, P. Harris, A. Paterson, Y. Pei   +7 more
semanticscholar   +1 more source

Insulin-like growth factor-1 induces hyperproliferation of PKD1 cystic cells via a Ras/Raf dependent signalling pathway [PDF]

, 2007
Autosomal dominant polycystic kidney disease (ADPKD) largely results from mutations in the PKD1 gene leading to hyperproliferation of renal tubular epithelial cells and consequent cyst formation.
Harris, P.C., Newby, L.J., O'Hare, O.J., Ong, A.C.M., Parker, E., Rossetti, S., Sharpe, C.C., Streets, A.J.   +7 more
core   +1 more source

Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
Importance Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation in both kidneys and loss of renal function, eventually leading to a need for kidney replacement therapy.
E. Meijer, F. W. Visser, René M M van Aerts, C. Blijdorp, N. Casteleijn, Hedwig M. A. D’Agnolo, S. Dekker, J. Drenth, J. D. de Fijter, M. V. van Gastel, T. Gevers, M. A. Lantinga, M. Losekoot, A. L. Messchendorp, M. Neijenhuis, M. Pena, D. Peters, M. Salih, D. Soonawala, E. M. Spithoven, J. Wetzels, R. Zietse, R. Gansevoort   +22 more
semanticscholar   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source