Results 61 to 70 of about 488,068 (360)

Identification, Characterization, and Localization of a Novel Kidney Polycystin-1-Polycystin-2 Complex [PDF]

, 2002
The functions of the two proteins defective in autosomal dominant polycystic kidney disease, polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that they may heterodimerize to form a "polycystin complex" involved ...
Ackermann, Bergsma, Boletta, Cai, Charron, Chen, Foggensteiner, Gallagher, Gonzalez-Perrett, Green, Grupp, Hanaoka, Huan, Hughes, Ibraghimov Beskrovnaya, Ibraghimov Beskrovnaya, Jat, Jat, Lehtonen, Lohning, Lu, Man, Markowitz, Mochizuki, Moy, Nathke, Obermuller, Olmsted, Ong, Ong, Ong, Ong, Pollack, Pritchard, Putney, Qian, Rothman, Scheffers, Tsiokas, Vassilev, Ward, Watnick, Wu, Xu   +43 more
core   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Automatic Segmentation of Kidneys using Deep Learning for Total Kidney Volume Quantification in Autosomal Dominant Polycystic Kidney Disease

Scientific Reports, 2017
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited disorder of the kidneys. It is characterized by enlargement of the kidneys caused by progressive development of renal cysts, and thus assessment of total kidney volume (TKV)
Kanishka Sharma, C. Rupprecht, A. Caroli, M. C. Aparicio, A. Remuzzi, Maximilian Baust, Nassir Navab   +6 more
semanticscholar   +1 more source

Polycystic kidney disease in a Persian cat [PDF]

, 2015
A 6-year-old intact Persian cat was presented for the primary complaint of inappetence and weight loss. Irregular surface of kidneys was palpated during physical examination. Abdominal radiograph findings were indicative of renomegaly.
Khor, Kuan Hua, Lau, Seng Fong, Phoon, Melissa Hoi Ee, Saw, Ming Hooi   +3 more
core  

Nonobstructing Colonic Dilatation and Colon Perforations Following Renal Transplantation [PDF]

, 1990
Nonobstructing colonic dilatation has not been commonly reported following renal transplantation, and colon perforations carry a high morbidity and mortality in this population.
Hakala, TR, Koneru, B, O'hair, DP, Selby, R, Starzl, TE, Tzakis, AG   +5 more
core   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Characterizing the ADPKD-IFT140 Phenotypic Signature With Deep Learning and Advanced Imaging Biomarkers

Kidney International Reports
Introduction: ADPKD-IFT140 is the third most common disease-causing variant in autosomal dominant polycystic kidney disease (ADPKD) after ADPKD-PKD1 and ADPKD-PKD2.
Ahmad Ghanem, Fadi George Munairdjy Debeh, Abdul Hamid Borghol, Nikola Zagorec, Amanda L. Tapia, Byron Smith, Stefan Paul, Abdul Basit, Bassel AlKhatib, Nay Nader, Marie Therese Bou Antoun, Adriana V. Gregory, Hana Yang, Rachel S. Schauer, Neera K. Dahl, Christian Hanna, Vicente E. Torres, Timothy L. Kline, Peter C. Harris, Emilie Cornec-Le Gall, Fouad T. Chebib   +20 more
doaj   +1 more source

Glomerular Basement Membrane Protein Expression and the Diagnosis and Prognosis of Autosomal Dominant Alport Syndrome

Kidney Medicine, 2019
Alport syndrome is a hereditary glomerular nephritis associated with hearing loss and eye abnormalities and is classified as X-linked Alport syndrome, autosomal recessive Alport syndrome, and autosomal dominant Alport syndrome.
Taro Akihisa, Masayo Sato, Yoshie Wakayama, Sekiko Taneda, Shigeru Horita, Orie Hirose, Shiho Makabe, Hiroshi Kataoka, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Kosaku Nitta, Toshio Mochizuki   +12 more
doaj   +1 more source

A Review of Rare Associations of Horseshoe Kidney: Highlight of a Rare Clinical Case of Polycystic Horseshoe Kidney, Liver Cyst, and Uterine Prolapse

European Medical Journal Urology, 2020
Horseshoe kidney is the most common renal fusion anomaly occurring in 0.15–0.25% of the general population. Horseshoe kidney is usually asymptomatic but may present with disease-like infections, urolithiasis, malignancy, polycystic disease, and other ...
Ayun Cassell, Mohamed Jalloh, Papa S. Diop, Mouhamadou M. Mbodji, Medina Ndoye, Abdourahmane Diallo, Saint Charles Kouka, Issa Labou, Lamine Niang, Serigne M. Gueye   +9 more
doaj   +1 more source

Polycystic kidney disease

InnovAiT: Education and inspiration for general practice, 2020
Polycystic kidney disease (PKD) is a monogenic, hereditary disorder of the kidneys that leads to fluid-filled cysts within the renal tubes. It is one of the most common causes of end-stage renal failure. There are two types, the more common autosomal dominant (ADPKD) and the rarer autosomal recessive (ARPKD).
Soo Oh, Rabeet Khan, Ahmed Ziada
openaire   +2 more sources