Results 81 to 90 of about 462,629 (365)

Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development

Developmental Dynamics, EarlyView.
Abstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Stephen Spurgin, Ange Michelle Nguimtsop, Fatima N. Chaudhry, Sylvia N. Michki, Jocelynda Salvador, M. Luisa Iruela‐Arispe, Jarod A. Zepp, Saikat Mukhopadhyay, Ondine Cleaver   +8 more
wiley   +1 more source

Coronary Artery Ectasia in a Patient with Polycystic Kidney Disease

Journal of Cardiovascular and Thoracic Research, 2011
A 44 years old male patient with acute coronary syndrome and polycystic kidney disease is described. Coronary angiography showed ectatic coronary arteries.
Leili Pourafkari, Samad Ghaffari, Bizhan Zamani, Mehdi Tolui   +3 more
doaj   +1 more source

Autosomal Dominant Polycystic Kidney Disease: Core Curriculum 2016.

American Journal of Kidney Diseases, 2016
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease. It is characterized by relentless development of kidney cysts, hypertension, and eventually end-stage renal disease (ESRD).
F. Chebib, V. Torres
semanticscholar   +1 more source

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 ...
Bourgeois, Bryan C, Kruger, Samantha L, Shillingford, Jonathan M, Torres, Jacob, Weimbs, Thomas   +4 more
core   +1 more source

Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats [PDF]

, 2019
Male Cy/+ rats have shown a relatively consistent pattern of progressive kidney disease development that displays multiple key features of late stage chronic kidney disease-mineral bone disorder (CKD-MBD), specifically the development of cortical bone ...
Allen, Matthew R., Chen, Neal X., Hill Gallant, Kathleen M., Lachcik, Pamela J., Metzger, Corinne E., Moe, Sharon M., Swallow, Elizabeth A., Vorland, Colby J.   +7 more
core   +1 more source

Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice

Nephrology, Dialysis and Transplantation, 2016
Recently, the European Medicines Agency approved the use of the vasopressin V2 receptor antagonist tolvaptan to slow the progression of cyst development and renal insufficiency of autosomal dominant polycystic kidney disease (ADPKD) in adult patients ...
R. Gansevoort, M. Arıcı, T. Benzing, H. Birn, G. Capasso, A. Covic, O. Devuyst, C. Drechsler, K. Eckardt, F. Emma, B. Knebelmann, Y. Le Meur, Z. Massy, A. Ong, A. Ortiz, F. Schaefer, R. Torra, R. Vanholder, A. Więcek, C. Zoccali, W. van Biesen   +20 more
semanticscholar   +1 more source

A One Health overview, facilitating advances in comparative medicine and translational research. [PDF]

, 2016
Table of contentsA1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey ...
Baron, David A, Bergman, Philip J, Bryan, Jeffrey N, Calvet, James P, Coates, Joan R, Cook, James L, Curiel, David T, Dmitriev, Igor, Duan, Dongsheng, Engiles, Julie B, Gandolfi, Barbara, Gaurnier-Hausser, Anita, Gnanandarajah, Josephine S, Gray, Falon, Guloy, Amado S, Harman, Robert J, Hays, Harlen D, Henry, Carolyn J, Huebner, Margie, Jacobs, Marc, Johnson, Gary S, Johnson, Gayle C, Karanu, Francis N, Kashentseva, Elena, Katz, Martin L, Laughlin, Danielle, LeBlanc, Amy K, Likins, Lee, Lyons, Leslie A, Mason, Nicola J, O'Brien, Dennis P, O'Connor, Daniel, Paterson, Yvonne, Reinero, Carol, Rindt, Hans, Robb, Edward J, Sabbagh, Ubadah, Skaff, Andrew, Stannard, James P, Stroud, Cheryl, Treml, Laura S, Wallecha, Anu, Webster, Debra A, Weiss, Mark L, Wyckoff, Gerald J   +44 more
core   +2 more sources

Efficacy of hormone pre‐treatment before ART to improve reproductive outcomes in infertile women with endometriosis: Network meta‐analysis of randomized controlled trials

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Hormone pre‐treatment is still used before assisted reproductive technique (ART) in endometriotic women, but evidence supporting this recommendation is conflicting. Objectives To evaluate whether hormone pre‐treatment with gonadotropin‐releasing hormone (GnRH) agonists or progestogens could improve fertility in women with ...
Gaetano Riemma, Luigi Cobellis, Antonio Simone Laganà, Andrea Etrusco, Luigi Della Corte, Marco Torella, Maria Giovanna Vastarella, Raffaela Maria Carotenuto, Pasquale De Franciscis   +8 more
wiley   +1 more source

Chinese clinical practice guide for autosomal dominant polycystic kidney disease

Linchuang shenzangbing zazhi, 2019
常染色体显性多囊肾病(autosomal dominant polycystic kidney disease, ADPKD)是最常见的遗传性肾病,患病率为1/400～1/1000[1]。ADPKD主要致病基因有两个,PKD1和PKD2,其突变导致疾病分别约占发病人群的85%和15%[2-3]。该病为常染色体显性遗传病,子代发病机率为50%。患者多在成年后出现双侧肾脏囊肿,随年龄增长,逐渐损害肾脏结构和功能[4 ...
Expert Committee on Clinical Practice Guidelines for Autosomal Dominant Polycystic Kidney Disease
doaj  

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

Nature Communications, 2017
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report that miR-17 is induced in kidney cysts of mouse and human ADPKD.
Sachin S Hajarnis, R. Lakhia, Matanel Yheskel, Darren Williams, Mehran Sorourian, Xueqing Liu, Karam Aboudehen, Shanrong Zhang, Kara Kersjes, R. Galasso, Jian Li, V. Kaimal, S. Lockton, Scott Davis, Andrea Flaten, Joshua A. Johnson, W. Holland, C. Kusminski, P. Scherer, P. Harris, M. Trudel, D. Wallace, P. Igarashi, Edmund C. Lee, J. Androsavich, V. Patel   +25 more
semanticscholar   +1 more source